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Literature DB >> 4317923

Tilorone hydrochloride: an orally active antiviral agent.

Abstract

Tilorone hydrochloride, 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one dihydrochloride, given orally to mice before they are infected is active against at least nine viruses of both RNA and DNA groups. The compound is effective when given prophylactically; the optimum time of treatment depends on the route of infection.

Entities: Chemical Disease Species

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Year: 1970 PMID： 4317923 DOI： 10.1126/science.169.3951.1213

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

43 in total

1. Comparation interferon- inducing and antiviral properties of 2-amino-5-bromo-6-methyl-4-pyrimidinol (U-25,166), tilorone hydrochloride, and polyinosinic-polycytidylic acid.

Authors: D A Stringfellow
Journal: Antimicrob Agents Chemother Date: 1977-06 Impact factor: 5.191

2. Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection.

Authors: Sean Ekins; Mary A Lingerfelt; Jason E Comer; Alexander N Freiberg; Jon C Mirsalis; Kathleen O'Loughlin; Anush Harutyunyan; Claire McFarlane; Carol E Green; Peter B Madrid
Journal: Antimicrob Agents Chemother Date: 2018-01-25 Impact factor: 5.191

3. Stimulation of humoral immune response by tilorone hydrochloride.

Authors: T Diamantstein
Journal: Immunology Date: 1973-04 Impact factor: 7.397

4. The protective effect of the interferon inducers tilorone hydrochloride and Poly I:C on experimental tick-borne encephalitis in mice.

Authors: H Hofmann; C Kunz
Journal: Arch Gesamte Virusforsch Date: 1972

5. Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.

Authors: Rajiv R Ratan; Ambreena Siddiq; Leila Aminova; Brett Langley; Stephen McConoughey; Ksenia Karpisheva; Hsin-Hwa Lee; Thomas Carmichael; Harley Kornblum; Giovanni Coppola; Daniel H Geschwind; Ahmet Hoke; Natalya Smirnova; Cameron Rink; Sashwati Roy; Chandan Sen; Michael S Beattie; Ron P Hart; Martin Grumet; Dongming Sun; Robert S Freeman; Gregg L Semenza; Irina Gazaryan
Journal: Ann N Y Acad Sci Date: 2008-12 Impact factor: 5.691

Tilorone hydrochloride: an orally active antiviral agent.

1. Comparation interferon- inducing and antiviral properties of 2-amino-5-bromo-6-methyl-4-pyrimidinol (U-25,166), tilorone hydrochloride, and polyinosinic-polycytidylic acid.

2. Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection.

3. Stimulation of humoral immune response by tilorone hydrochloride.

4. The protective effect of the interferon inducers tilorone hydrochloride and Poly I:C on experimental tick-borne encephalitis in mice.

5. Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.

6. Tilorone hydrochloride: an oral interferon-inducing agent.

7. Tilorone hydrochloride: lack of correlation between interferon induction and viral protection.

8. Effect of tilorone on susceptibility of mice to primary or secondary infection with Listeria monocytogenes.

9. alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues.

10. Evaluation of various analogues of tilorone hydrochloride against Venezuelan equine encephalitis virus in mice.