Literature DB >> 462129

Tetracyclines and host defense mechanisms: interference with leukocyte chemotaxis.

J Belsheim, H Gnarpe, S Persson.   

Abstract

The influence of 2 etracycline preparations, lymecycline and doxycycline, on leukocyte chemotaxis, was investigated in vitro and in vivo. Doxycycline in high concentrations caused a severe depression of both spontaneous and induced migration, an effect which was more pronounced than that caused by similar concentration of lymecycline. Corresponding results were obtained both in experiments on healthy volunteers given recommended dosages of the antibiotics, and in patients treated with doxycycline for postoperative infections.

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Year:  1979        PMID： 462129     DOI： 10.3109/inf.1979.11.issue-2.08

Source DB:  PubMed          Journal:  Scand J Infect Dis        ISSN： 0036-5548


  7 in total

1.  Effect of a single oral dose of doxycycline on polymorphonuclear leukocyte migration in a casein gradient.

Authors:  O Bäck; B Norberg
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953

2.  Effect of phenoxymethylpenicillin, erythromycin, lymecycline and doxycycline upon the release of proteases from human leukocytes.

Authors:  S Engquist; C Lundberg; C Petterson
Journal:  Eur J Clin Microbiol       Date:  1983-06       Impact factor: 3.267

3.  In vitro activities of azithromycin and doxycycline against 15 isolates of Chlamydia pneumoniae.

Authors:  J Gnarpe; K Eriksson; H Gnarpe
Journal:  Antimicrob Agents Chemother       Date:  1996-08       Impact factor: 5.191

4.  Stimulation of granulocyte functions in vitro by imipenem and the renal enzyme inhibitor MK 0791.

Authors:  H Gnarpe; J Belsheim; C Blomqvist; A Lundbäck
Journal:  Antimicrob Agents Chemother       Date:  1984-02       Impact factor: 5.191

5.  Predisposing factors in Pneumocystis carinii pneumonia: effects of tetracycline, protein malnutrition, and corticosteroids on hosts.

Authors:  P D Walzer; M LaBine; T J Redington; M T Cushion
Journal:  Infect Immun       Date:  1984-12       Impact factor: 3.441

6.  Chemoattractive factors from Escherichia coli: individual strain variation.

Authors:  J Belsheim; H Gnarpe; B Kaijser
Journal:  Infect Immun       Date:  1981-01       Impact factor: 3.441

7.  Effect of amoxycillin and doxycycline on function of human granulocytes tested in vitro and on chemotaxis of granulocytes from rabbits given the two antibiotics.

Authors:  V Grec; P C Frei
Journal:  Inflammation       Date:  1984-12       Impact factor: 4.092
  7 in total

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