Literature DB >> 4597122

Gastric response to metiamide.

B Thjodleifsson, K G Wormsley.   

Abstract

Metiamide greatly reduced pentagastrin-stimulated and overnight secretion of acid and pepsin in 11 patients with duodenal ulcer and virtually abolished gastric secretion in three patients with gastric ulcer. The drug was equally effective when infused intravenously or intraduodenally. A therapeutic trial of Metiamide is warranted in diseases caused or aggravated by excess gastric secretion of acid and pepsin.

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Year:  1974        PMID： 4597122      PMCID： PMC1610965          DOI： 10.1136/bmj.2.5914.304

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  3 in total

1.  A method for estimating peptic activity in gastric contents.

Authors:  J N Hunt
Journal:  Biochem J       Date:  1948       Impact factor: 3.857

2.  Serial studies of gastric secretion in patients after highly selective (parietal cell) vagotomy without a drainage procedure for duodenal ulcer. I. Effect of highly selective vagotomy on basal and pentagastrin-stimulated maximal acid output.

Authors:  D Johnston; A R Wilkinson; C S Humphrey; R B Smith; J C Goligher; E Kragelund; E Amdrup
Journal:  Gastroenterology       Date:  1973-01       Impact factor: 22.682

3.  Inhibition of gastric secretion in man by metiamide: a new, orally active histamine H 2 -receptor antagonist.

Authors:  J H Wyllie; W D Ealding; T Hesselbo; J W Plack
Journal:  Gut       Date:  1973-05       Impact factor: 23.059
  3 in total
  17 in total

1.  The effect of prolonged metiamide administration on gastric acid secretion in man.

Authors:  G O Barbezat; S Bank
Journal:  Am J Dig Dis       Date:  1976-06

2.  Editorial: Histamine antagonists and peptic ulcer.

Authors: 
Journal:  Br Med J       Date:  1976-04-03

Review 3.  Drugs in the treatment of gastric and duodenal ulcer.

Authors:  M J Langman
Journal:  Drugs       Date:  1977-08       Impact factor: 9.546

4.  Effect of metiamide on the response to secretin and cholecystokinin in man.

Authors:  B Thjodleifsson; K G Wormsley
Journal:  Gut       Date:  1975-01       Impact factor: 23.059

5.  Classification and biological distribution of histamine receptor sub-types.

Authors:  N Chand; P Eyre
Journal:  Agents Actions       Date:  1975-10

6.  Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man.

Authors:  W L Burland; W A Duncan; T Hesselbo; J G Mills; P C Sharpe; S J Haggie; J H Wyllie
Journal:  Br J Clin Pharmacol       Date:  1975-12       Impact factor: 4.335

7.  Aspects of the effect of metiamide on pentagastrin-stimulated and basal gastric secretion of acid and pepsin in man.

Authors:  B Thjodleifsson; K G Wormsley
Journal:  Gut       Date:  1975-07       Impact factor: 23.059

8.  Early clinical experience with metiamide, a histamine H2-receptor antagonist, in patients with duodenal ulcer.

Authors:  M H Thompson; J D Reed; G Dale; C W Venables
Journal:  Am J Dig Dis       Date:  1975-12

9.  24-hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer during oral administration of cimetidine and atropine.

Authors:  R E Pounder; R H Hunt; S H Vincent; G J Milton-Thompson; J J Misiewicz
Journal:  Gut       Date:  1977-02       Impact factor: 23.059

10.  Complete inhibition of food-stimulated gastric acid secretion by combined application of pirenzepine and ranitidine.

Authors:  W Londong; V Londong; C Ruthe; P Weizert
Journal:  Gut       Date:  1981-07       Impact factor: 23.059
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