Literature DB >> 1098968

Aspects of the effect of metiamide on pentagastrin-stimulated and basal gastric secretion of acid and pepsin in man.

B Thjodleifsson, K G Wormsley.   

Abstract

This study has examined the inhibition produced by metiamide on the gastric secretion of acid and pepsin in 13 patients with duodenal and three with gastric ulcer. The effect of metiamide on the response to a range of doses of pentagastrin in three normal individuals was determined, as was the interaction of metiamide and atropine on prolonged basal secretion. Metiamide inhibited the secretion of acid more than pepsin and the gastric secretion of patients with gastric ulcer more than duodenal ulcer. Metiamide inhibited both the maximal secretory response attainable with pentagastrin and decreased the sensitivity to pentagastrin. Atropine augmented and prolonged the action of metiamide.

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Year:  1975        PMID： 1098968      PMCID： PMC1410974          DOI： 10.1136/gut.16.7.501

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  16 in total

1.  A COMPARISON OF ESTIMATES OF MICHAELIS-MENTEN KINETIC CONSTANTS FROM VARIOUS LINEAR TRANSFORMATIONS.

Authors:  J E DOWD; D S RIGGS
Journal:  J Biol Chem       Date:  1965-02       Impact factor: 5.157

2.  Importance of vagal innervation in the regulatory effect of acid in the duodenum on gastric secretion of acid.

Authors:  C F CODE; G WATKINSON
Journal:  J Physiol       Date:  1955-10-28       Impact factor: 5.182

3.  A method for estimating peptic activity in gastric contents.

Authors:  J N Hunt
Journal:  Biochem J       Date:  1948       Impact factor: 3.857

4.  Definition and antagonism of histamine H 2 -receptors.

Authors:  J W Black; W A Duncan; C J Durant; C R Ganellin; E M Parsons
Journal:  Nature       Date:  1972-04-21       Impact factor: 49.962

5.  Inhibition of nocturnal acid secretion in duodenal ulcer by one oral dose of metiamide.

Authors:  G J Milton-Thompson; J G Williams; D J Jenkins; J J Misiewicz
Journal:  Lancet       Date:  1974-04-20       Impact factor: 79.321

6.  Gastrin, cholecystokinin, and secretin act on one receptor.

Authors:  M I Grossman
Journal:  Lancet       Date:  1970-05-23       Impact factor: 79.321

7.  Metiamide--an orally active histamine H2-receptor antagonist.

Authors:  J W Black; W A Duncan; J C Emmett; C R Ganellin; T Hesselbo; M E Parsons; J H Wyllie
Journal:  Agents Actions       Date:  1973-10

8.  Metiamide, an H2-receptor blocker, as inhibitor of basal and meal-stimulated gastric acid secretion in patients with duodenal ulcer.

Authors:  M Mainardi; V Maxwell; R A Sturdevant; J I Isenberg
Journal:  N Engl J Med       Date:  1974-08-22       Impact factor: 91.245

9.  Actions of metiamide, an H2-histamine receptor antagonist, on gastric H+ and pepsin secretion in dogs.

Authors:  R Gibson; B I Hirschowitz; G Hutchison
Journal:  Gastroenterology       Date:  1974-07       Impact factor: 22.682

10.  Effect of metiamide on histamine metabolism in man.

Authors:  D M Shepherd; B Thjodleifsson; M J Turnbull; K G Wormsley
Journal:  Digestion       Date:  1974       Impact factor: 3.216
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  12 in total

1.  The isolated stomach preparation of the mouse: a physiological unit for pharmacological analysis.

Authors:  J W Black; N P Shankley
Journal:  Br J Pharmacol       Date:  1985-11       Impact factor: 8.739

2.  Analysis of the interaction between histamine H2-receptor antagonists and pentagastrin [proceedings].

Authors:  J W Black; D H Jenkinson; L Welch
Journal:  Agents Actions       Date:  1978-06

3.  Hormonal control of parietal cell function.

Authors:  A H Soll
Journal:  World J Surg       Date:  1979-08-31       Impact factor: 3.352

4.  Interaction of glucagon and pentagastrin on pepsin secretion in healthy subjects.

Authors:  J Christiansen; J J Holst; J Molin
Journal:  Gut       Date:  1982-06       Impact factor: 23.059

5.  Histamine and peptic ulcer: a prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases.

Authors:  H Troidl; W Lorenz; H Rohde; G Häfner; M Ronzheimer
Journal:  Klin Wochenschr       Date:  1976-10-01

6.  Gastrin stimulated H+ secretion in amphibian gastric mucosa: effect of tetrodotoxin.

Authors:  J G Spenney
Journal:  Experientia       Date:  1978-05-15

7.  Inhibitory effect of cimetidine on gastric acid secretion vagally activated by physiological means in duodenal ulcer patients.

Authors:  I M Schöön; L Olbe
Journal:  Gut       Date:  1978-01       Impact factor: 23.059

8.  The interaction of histamine with gastrin and carbamylcholine on oxygen uptake by isolated mammalian parietal cells.

Authors:  A H Soll
Journal:  J Clin Invest       Date:  1978-02       Impact factor: 14.808

9.  Metiamide and stimulated acid secretion from the isolated non-distended and distended mouse stomach.

Authors:  B Y Wan
Journal:  J Physiol       Date:  1977-04       Impact factor: 5.182

10.  Inhibition of basal and stimulated gastric H+ and pepsin secretion in duodenal ulcer patients by metiamide, an H-2 histamine antagonist.

Authors:  S C Bajaj; B I Hirschowitz
Journal:  Am J Dig Dis       Date:  1976-07
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