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Literature DB >> 4597116

Silver sulfadiazine: effect on the growth and metabolism of bacteria.

Abstract

Even though the addition of silver sulfadiazine (AgSu) to purified deoxyribonucleic acid (DNA) results in the formation of AgSu-DNA complexes, no such complexes were detected in bacteria treated with AgSu. AgSu blocked macromolecular syntheses in treated bacteria, DNA synthesis being slightly more sensitive to this inhibitory action. The ribosomes, ribonucleic acid, and DNA isolated from treated cells were normal qualitatively. Bacteria deficient in DNA polymerase were not more sensitive than their parent strain to the lethal action of AgSu. Radioactive AgSu was localized mainly in the cytoplasmic membrane fraction of treated cells.

Entities: Chemical

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Year: 1972 PMID： 4597116 PMCID： PMC444322 DOI： 10.1128/AAC.2.5.367

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

26 in total

Silver sulfadiazine: effect on the growth and metabolism of bacteria.

1. On the complexing of deoxyribonucleic acid by silver (I).

2. Rapid detection of mutagens and carcinogens.

3. Synthesis and maturation of ribosomal RNA in Escherichia coli.

4. Effects of N-hydroxyurethan on viability and metabolism of Escherichia coli.

5. Electrophoretic separation of viral nucleic acids on polyacrylamide gels.

6. Changes in the structure and activity of lambda DNA in a superinfected immune bacterium.

7. Clinical experience with silver sulfadiazine, a new topical agent for control of pseudomonas infections in burns.

8. Possible hazard in use of gentian violet.

9. Silver sulfadiazine: interaction with isolated deoxyribonucleic acid.

10. Effects of acridine orange on the growth of Escherichia coli.

1. Antifungal properties of electrically generated metallic ions.

2. Electrochemical Ag+ for preservative use.

3. Effects of microamperage, medium, and bacterial concentration on iontophoretic killing of bacteria in fluid.

4. Electrically generated silver ions: quantitative effects on bacterial and mammalian cells.

5. Heavy metal resistance in clinical isolates of Pseudomonas aeruginosa.

6. Adherence of organisms to silver-coated surfaces.

7. Plasmid-determined silver resistance in Pseudomonas stutzeri isolated from a silver mine.

8. Silver sulfadiazine: interaction with isolated deoxyribonucleic acid.

9. The electrified catheter. Role in sterilizing urine and decreasing bacteriuria.

10. Reversal of the silver inhibition of microorganisms by agar.