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Literature DB >> 4583252

Modification of ribosomes in cryptopleurine-resistant mutants of yeast.

Abstract

Cryptopleurine-resistant mutants of Saccharomyces cerevisiae were isolated. A single, recessive nuclear gene, very closely linked to the mating locus (2.1 centimorgans), is responsible for resistance. Ribosomes from the mutants were found to be resistant to cryptopleurine when analyzed by poly(U)-directed polyphenylalanine synthesis. Analysis of the distribution of ribosomes between monosomes and polysomes in sensitive cells exposed to cryptopleurine suggests that some step is inhibited during the elongation phase of protein synthesis.

Entities: Chemical Species

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Year: 1973 PMID： 4583252 PMCID： PMC285451 DOI： 10.1128/jb.116.2.818-822.1973

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

11 in total

1. Mode of action of tylocrebrine: effects on protein and nucleic acid synthesis.

Authors: M T Huang; A P Grollman
Journal: Mol Pharmacol Date: 1972-09 Impact factor: 4.436

2. Hydrolysis of guanosine 5'-triphosphate associated wh binding of aminoacyl transfer ribonucleic acid to ribosomes.

Authors: J Gordon
Journal: J Biol Chem Date: 1969-10-25 Impact factor: 5.157

3. Formation of a ternary complex between yeast aminoacyl-tRNA binding factor, GTP, and aminoacyl-tRNA.

Authors: D Richter
Journal: Biochem Biophys Res Commun Date: 1970-03-12 Impact factor: 3.575

4. Differentiation in vitro by phenanthrene alkaloids of yeast mitochondrial protein synthesis from ribosomal systems of both yeast and bacteria.

Authors: J M Haslam; P J Davey; A W Linnane; M R Atkinson
Journal: Biochem Biophys Res Commun Date: 1968-11-08 Impact factor: 3.575

5. Inhibition of protein synthesis in Ehrlich ascites-tumour cells by the phenanthrene alkaloids tylophorine, tylocrebrine and cryptopleurine.

Authors: G R Donaldson; M R Atkinson; A W Murray
Journal: Biochem Biophys Res Commun Date: 1968-04-05 Impact factor: 3.575

6. Studies on transfer ribonucleic acid-ribosome complexes. XXI. Effect of antibiotics on peptidyl-puromycin synthesis by mammalian polyribosomes.

Authors: S Pestka; H Rosenfeld; R Harris; H Hintikka
Journal: J Biol Chem Date: 1972-11-10 Impact factor: 5.157

7. Temperature-sensitive mutants of yeast exhibiting a rapid inhibition of protein synthesis.

Authors: L H Hartwell; C S McLaughlin
Journal: J Bacteriol Date: 1968-11 Impact factor: 3.490

8. Inhibitors of protein synthesis by ribosomes of the 80-S type.

Authors: E Battaner; D Vazquez
Journal: Biochim Biophys Acta Date: 1971-12-16

9. Genetic mapping in Saccharomyces.

Authors: R K Mortimer; D C Hawthorne
Journal: Genetics Date: 1966-01 Impact factor: 4.562

10. Macromolecule synthesis in temperature-sensitive mutants of yeast.

Authors: L H Hartwell
Journal: J Bacteriol Date: 1967-05 Impact factor: 3.490

37 in total

1. Study on proteins from yeast cytoplasmic ribosomes by two-dimensional gel electrophoresis.

Authors: J Ishiguro
Journal: Mol Gen Genet Date: 1976-04-23

2. Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae.

Authors: L C Kadyk; L H Hartwell
Journal: Genetics Date: 1992-10 Impact factor: 4.562

3. A ribosome-dependent GTPase from yeast distinct from elongation factor 2.

Authors: L Skogerson; E Wakatama
Journal: Proc Natl Acad Sci U S A Date: 1976-01 Impact factor: 11.205

4. Ribosomal suppressors and antisuppressors in Podospora anserina: resistance to cycloheximide.

Authors: E Coppin-Raynal
Journal: J Bacteriol Date: 1977-09 Impact factor: 3.490

Review 5. Genetic map of Saccharomyces cerevisiae, edition 9.

Authors: R K Mortimer; D Schild
Journal: Microbiol Rev Date: 1985-09

6. Resistance against cycloheximide in cell lines from Chinese hamster and human cells is conferred by the large subunit of cytoplasmic ribosomes.

Authors: H Pöche; S Zakrzewski; K H Nierhaus
Journal: Mol Gen Genet Date: 1979-09

7. Molecular genetics of cryptopleurine resistance in Saccharomyces cerevisiae: expression of a ribosomal protein gene family.

Authors: A G Paulovich; J R Thompson; J C Larkin; Z Li; J L Woolford
Journal: Genetics Date: 1993-11 Impact factor: 4.562