Literature DB >> 818503

Thiostrepton-resistant mutants of Bacillus subtilis: localization of resistance to the 50S subunit.

S Pestka, D Weiss, R Vince, B Wienen, G Stöffler, I Smith.   

Abstract

A number of thiostrepton-resistant mutants of Bacillus subtilis were obtained. The thi mutations map proximally to strA. Effects of thiostrepton on polyphenylalanine synthesis with ribosomes of S-100 fractions from parent and mutant strains indicated that resistance was localized to the ribosomes. Furthermore, effects of thiostrepton on binding of [3H]GTP to ribosomes and 50S subunits from thiostrepton-sensitive and -resistant strains localized the site of resistance to the 50S subunit. In addition, revertants from thiostrepton-resistance to thiostrepton-sensitivity were obtained. Ribosomes and 50S subunits from these thiostrepton-sensitive revertants were sensitive to thiostrepton similar to parental sensitive B. subtilis.

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Year:  1976        PMID： 818503     DOI： 10.1007/BF00341721

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  32 in total

1.  Modes of action of erythromycin and thiostrepton as inhibitors of protein synthesis.

Authors:  Michael Cannon; Kay Burns
Journal:  FEBS Lett       Date:  1971-10-15       Impact factor: 4.124

2.  Inhibition by thiostrepton of the formation of a ribosome-bound guanine nucleotide complex.

Authors:  B Weisblum; V Demohn
Journal:  FEBS Lett       Date:  1970-12       Impact factor: 4.124

3.  Thiostrepton: a ribosomal inhibitor of translocation.

Authors:  S Pestka
Journal:  Biochem Biophys Res Commun       Date:  1970-08-11       Impact factor: 3.575

4.  Relation between the ribosomal sites involved in initiation and elongation of polypeptide chains. Evidence for two guanosine triphosphatase sites.

Authors:  A H Lockwood; U Maitra
Journal:  J Biol Chem       Date:  1974-01-25       Impact factor: 5.157

5.  Ribosomal proteins. II. A rapid micromethod for electrophoretic separation of Escherichia coli ribosomal protein on gelatinized cellulose acetate.

Authors:  G Stöffler
Journal:  Mol Gen Genet       Date:  1967

6.  Genetic mapping in Bacillus subtilis.

Authors:  D Dubnau; C Goldthwaite; I Smith; J Marmur
Journal:  J Mol Biol       Date:  1967-07-14       Impact factor: 5.469

7.  Regulatory mechanisms and protein synthesis. X. Codon recognition on 30 S ribosomes.

Authors:  S Pestka; M Nirenberg
Journal:  J Mol Biol       Date:  1966-10-28       Impact factor: 5.469

8.  Inhibition by thiopeptin of ribosomal functions associated with T and G factors.

Authors:  T Kinoshita; Y Liou; N Tanaka
Journal:  Biochem Biophys Res Commun       Date:  1971-08-20       Impact factor: 3.575

9.  Effect of siomycin on the acceptor site of Escherichia coli ribosomes.

Authors:  S Watanabe; K Tanaka
Journal:  Biochem Biophys Res Commun       Date:  1971-11-05       Impact factor: 3.575

10.  Inhibition by siomycin and thiostrepton of both aminoacyl-tRNA and factor G binding to ribosomes.

Authors:  J Modolell; B Cabrer; A Parmeggiani; D Vazquez
Journal:  Proc Natl Acad Sci U S A       Date:  1971-08       Impact factor: 11.205
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  9 in total

1.  Thiostrepton-resistant mutants exhibit relaxed synthesis of RNA.

Authors:  I Smith; P Paress; S Pestka
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

Review 2.  Revised genetic linkage map of Bacillus subtilis.

Authors:  P J Piggot; J A Hoch
Journal:  Microbiol Rev       Date:  1985-06

3.  Physiological analysis of the stringent response elicited in an extreme thermophilic bacterium, Thermus thermophilus.

Authors:  Koji Kasai; Tomoyasu Nishizawa; Kosaku Takahashi; Takeshi Hosaka; Hiroyuki Aoki; Kozo Ochi
Journal:  J Bacteriol       Date:  2006-10       Impact factor: 3.490

4.  Streptomyces relC mutants with an altered ribosomal protein ST-L11 and genetic analysis of a Streptomyces griseus relC mutant.

Authors:  K Ochi
Journal:  J Bacteriol       Date:  1990-07       Impact factor: 3.490

Review 5.  The Bacillus subtilis chromosome.

Authors:  D J Henner; J A Hoch
Journal:  Microbiol Rev       Date:  1980-03

6.  A micrococcin-resistant mutant of Bacillus subtilis: localization of resistance to the 50s subunit.

Authors:  I Smith; D Weiss; S Pestka
Journal:  Mol Gen Genet       Date:  1976-03-30

7.  Binding of thiostrepton to ribosomes from thiostrepton-sensitive and -resistant Bacillus subtilis strains.

Authors:  R Vince; D Weiss; J Gordon; G Howard; I Smith; S Pestka
Journal:  Antimicrob Agents Chemother       Date:  1976-04       Impact factor: 5.191

8.  A nuclear mutation conferring thiostrepton resistance in Chlamydomonas reinhardtii affects a chloroplast ribosomal protein related to Escherichia coli ribosomal protein L11.

Authors:  K B McElwain; J E Boynton; N W Gillham
Journal:  Mol Gen Genet       Date:  1993-12

9.  Functional homology between E. coli ribosomal protein L11 and B. megaterium protein BM-L11.

Authors:  M J Stark; E Cundliffe; J Dijk; G Stöffler
Journal:  Mol Gen Genet       Date:  1980
  9 in total

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