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Literature DB >> 458192

PUVA suppresses the proliferative stimulus produced by stripping on hairless mice.

P O Fritsch, F Gschnait, G Kaaserer, W Brenner, S Chaikittisilpa, H Hönigsmann, K Wolff.

Abstract

Hairless mice were fed with 8-methoxypsoralen by gastric tube and exposed to UVA light to produce threshold phototoxic reactions. 3H-thymidine autoradiography revealed no significant difference of the epidermal labelling index as compared to that of nonirradiated animals (4.8 vs 6.2). Single PUVA exposures performed 2,8,14 and 24 hr after tape stripping lead to suppression of a wave of synchronized DNA synthesis present in nonirradiated control animals. These data demonstrate different reactions of stripped and unstripped epidermis to PUVA exposures and offer indirect evidence for the suppression of DNA synthesis in hyperproliferative skin disorders by PUVA in vivo.

Entities: Chemical Disease Species

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Year: 1979 PMID： 458192 DOI： 10.1111/1523-1747.ep12581676

Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551

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Cited

7 in total

1. Autoradiographic and planimetric analyses of the inflammatory infiltrate in psoriatic lesions under PUVA-therapy.

Authors: M Landthaler; G Plewig; C Hofmann; O Braun-Falco
Journal: Arch Dermatol Res Date: 1980 Impact factor: 3.017

2. Photopromotion of sister chromatid exchanges by psoralen derivatives.

Authors: D M Carter; M F Lyons; D B Windhorst
Journal: Arch Dermatol Res Date: 1982 Impact factor: 3.017

3. Inhibitory effect of 8-methoxysporalen plus UVA (PUVA) on the systemic induction of contact sensitivity to dinitrochlorobenzene (DNCB) in guinea pigs.

Authors: J C Meyer; H P Grundmann; H Weiss
Journal: Arch Dermatol Res Date: 1980 Impact factor: 3.017

PUVA suppresses the proliferative stimulus produced by stripping on hairless mice.

1. Autoradiographic and planimetric analyses of the inflammatory infiltrate in psoriatic lesions under PUVA-therapy.

2. Photopromotion of sister chromatid exchanges by psoralen derivatives.

3. Inhibitory effect of 8-methoxysporalen plus UVA (PUVA) on the systemic induction of contact sensitivity to dinitrochlorobenzene (DNCB) in guinea pigs.

4. In vivo autoradiography and planimetry of epidermis in psoriatics under PUVA-therapy.

5. Comparison of the Effect of Skin Preparation Pads on Transepidermal Water Loss in Ex Vivo Human Skin.

6. Effect of physical stimuli on hair follicle deposition of clobetasol-loaded Lipid Nanocarriers.

7. Assessing the Impact of Mechanical Damage on Full-Thickness Porcine and Human Skin Using an In Vitro Approach.