Literature DB >> 4564153

Role of cord factor (trehalose-6,6'-dimycolate) in allergic granuloma formation in rabbits.

V L Moore, Q N Myrvik, M Kato.   

Abstract

The role of cord factor in BCG-induced pulmonary granulomas and local pulmonary delayed hypersensitivity (DH) was evaluated. Cord factor did not induce pulmonary granulomas comparable to those induced by killed BCG. The compound did not induce pulmonary DH that could be elicited by itself, purified protein derivative, or BCG. Cord factor-injected animals did not develop an accelerated pulmonary granulomatous response after challenge with killed BCG. Finally, cord factor did not elicit local pulmonary DH in BCG-sensitized animals. These results are discussed in relation to cord factor's role in antimicrobial immunity, granuloma formation, and antitumor immunity.

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Year:  1972        PMID： 4564153      PMCID： PMC422481          DOI： 10.1128/iai.6.1.5-8.1972

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

1.  Studies on the chemistry of the cord factor of Mycobacterium tuberculosis.

Authors:  H NOLL; H BLOCH
Journal:  J Biol Chem       Date:  1955-05       Impact factor: 5.157

2.  A study of macrophages and epitheloid-like cells from granulomatous (BCG-induced) lungs of rabbits.

Authors:  Q N MYRVIK; E S LEAKE; S OSHIMA
Journal:  J Immunol       Date:  1962-11       Impact factor: 5.422

3.  Migratory response of granulomatous alveolar cells from BCG-sensitized rabbits.

Authors:  B Galindo; Q N Myrvik
Journal:  J Immunol       Date:  1970-07       Impact factor: 5.422

4.  Immune response to sheep red blood cells in mice pretreated with mycobacterial fractions.

Authors:  A Bekierkunst; E Yarkoni; I Flechner; S Morecki; E Vilkas; E Lederer
Journal:  Infect Immun       Date:  1971-09       Impact factor: 3.441

5.  Granuloma formation around schistosome eggs as a manifestation of delayed hypersensitivity.

Authors:  K S Warren; E O Domingo; R B Cowan
Journal:  Am J Pathol       Date:  1967-11       Impact factor: 4.307

6.  Cellular reaction in the footpad and draining lymph nodes of mice induced by mycobacterial fractions and BCG bacilli.

Authors:  A Bekierkunst; I S Levij; E Yarkoni; E Vilkas; E Lederer
Journal:  Infect Immun       Date:  1971-09       Impact factor: 3.441

7.  Suppression of urethan-induced lung adenomas in mice treated with trehalose-6,6-dimycolate (cord factor) and living bacillus Calmette Guérin.

Authors:  A Bekierkunst; I S Levij; E Yarkoni
Journal:  Science       Date:  1971-12-17       Impact factor: 47.728

8.  Granuloma formation induced in mice by chemically defined mycobacterial fractions.

Authors:  A Bekierkunst; I S Levij; E Yarkoni; E Vilkas; A Adam; E Lederer
Journal:  J Bacteriol       Date:  1969-10       Impact factor: 3.490

9.  Effect of antimacrophage serum on dermal tuberculin sensitivity and allergic pulmonary granuloma formation in rabbits.

Authors:  V L Moore; Q N Myrvik
Journal:  Infect Immun       Date:  1970-12       Impact factor: 3.441

10.  Studies of a biochemical lesion in experimental tuberculosis in mice. V. Further study on a toxic lipid fraction in firmly bound lipids.

Authors:  M Kato; A Tanaka
Journal:  Am Rev Respir Dis       Date:  1967-09
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  8 in total

Review 1.  Mycobacterium.

Authors:  L Barksdale; K S Kim
Journal:  Bacteriol Rev       Date:  1977-03

2.  Granulomagenic activity of serologically active glycolipids from Mycobacterium bovis BCG.

Authors:  Z Reggiardo; A K Shamsuddin
Journal:  Infect Immun       Date:  1976-12       Impact factor: 3.441

3.  Granulomatous hypersensitivity to trehalose-6,6'-dimycolate (cord factor) in mice infected with BCG.

Authors:  A Bekierkunst; E Yarkoni
Journal:  Infect Immun       Date:  1973-04       Impact factor: 3.441

4.  Specificity of a BCG-induced pulmonary granulomatous response in rabbits.

Authors:  V L Moore; Q N Myrvik; E S Leake
Journal:  Infect Immun       Date:  1973-05       Impact factor: 3.441

5.  Granuloma formation by muramyl dipeptide associated with branched fatty acids, a structure probably essential for tubercle formation by Mycobacterium tuberculosis.

Authors:  K Emori; S Nagao; N Shigematsu; S Kotani; M Tsujimoto; T Shiba; S Kusumoto; A Tanaka
Journal:  Infect Immun       Date:  1985-07       Impact factor: 3.441

6.  Interstitial and hemorrhagic pneumonitis induced by mycobacterial trehalose dimycolate.

Authors:  J Seggev; M B Goren; R I Carr; C H Kirkpatrick
Journal:  Am J Pathol       Date:  1982-03       Impact factor: 4.307

7.  Granuloma formation by synthetic bacterial cell wall fragment: muramyl dipeptide.

Authors:  K Emori; A Tanaka
Journal:  Infect Immun       Date:  1978-02       Impact factor: 3.441

8.  Mycobacterial components responsible for the induction of a chronic immunological inflammatory response in rabbit lungs.

Authors:  V L Moore; Q N Myrvik
Journal:  Infect Immun       Date:  1974-07       Impact factor: 3.441
  8 in total

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