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Literature DB >> 16557920

Effect of antimacrophage serum on dermal tuberculin sensitivity and allergic pulmonary granuloma formation in rabbits.

Abstract

Anti-rabbit alveolar macrophage goat serum (AMS), adsorbed of hemolysins and hemagglutinins, exhibited complement-dependent cytotoxicity for the following rabbit target cells: alveolar macrophages, thymocytes, and kidney (RK-13) cells. The intravenous injection of AMS, sufficient to reduce markedly the dermal tuberculin reaction in BCG-sensitized rabbits, did not suppress the development of BCG-induced chronic and accelerated pulmonary granulomas. These observations are discussed in relation to delayed sensitivity, allergic granuloma formation, and cell-associated immunity.

Entities: Disease Species

Year: 1970 PMID： 16557920 PMCID： PMC416095 DOI： 10.1128/iai.2.6.810-814.1970

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

19 in total

Review 1. Review lecture. Immunosuppressive agents, with special reference to antilymphocytic serum.

Authors: P Medawar
Journal: Proc R Soc Lond B Biol Sci Date: 1969-11-18

2. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse.

Authors: E A Boyse; M Miyazawa; T Aoki; L J Old
Journal: Proc R Soc Lond B Biol Sci Date: 1968-06-11

Review 3. Cellular hypersensitivity and cellular immunity in the pathogensis of tuberculosis: specificity, systemic and local nature, and associated macrophage enzymes.

Authors: A M Dannenberg
Journal: Bacteriol Rev Date: 1968-06

8. The role of delayed hypersensitivity in granulomatous reactions to mycobacteria: 1. Relationship of delayed reaction size to severity of granulomatous reactions after intradermal injections of mycobacteria.

Authors: J D Reid; J B Mackay
Journal: Tubercle Date: 1967-06

5. Mycobacterial components responsible for the induction of a chronic immunological inflammatory response in rabbit lungs.

Authors: V L Moore; Q N Myrvik
Journal: Infect Immun Date: 1974-07 Impact factor: 3.441

6. Relationship of BCG-induced pulmonary delayed hypersensitivity to accelerated granuloma formation in rabbit lungs: effect of cortisone acetate.

Authors: V L Moore; Q N Myrvik
Journal: Infect Immun Date: 1973-05 Impact factor: 3.441

6 in total

Effect of antimacrophage serum on dermal tuberculin sensitivity and allergic pulmonary granuloma formation in rabbits.

Review 1. Review lecture. Immunosuppressive agents, with special reference to antilymphocytic serum.

2. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse.

Review 3. Cellular hypersensitivity and cellular immunity in the pathogensis of tuberculosis: specificity, systemic and local nature, and associated macrophage enzymes.

4. Migratory response of granulomatous alveolar cells from BCG-sensitized rabbits.

5. Nature and mode of action of antilymphocytic antiserum.

6. Allograft survival: effect of antiserums to thymus glands and lymphocytes.

7. Recent studies on acquired immunity in tuberculosis.

8. The role of delayed hypersensitivity in granulomatous reactions to mycobacteria: 1. Relationship of delayed reaction size to severity of granulomatous reactions after intradermal injections of mycobacteria.

9. Granuloma formation induced in mice by chemically defined mycobacterial fractions.

10. Acute granulomatous response produced in mice by trehalose-6,6-dimycolate.

1. Comparative densities of hydrolase-containing granules from normal and BCG-induced alveolar macrophages.

2. Granulomagenic activity of serologically active glycolipids from Mycobacterium bovis BCG.

3. Specificity of a BCG-induced pulmonary granulomatous response in rabbits.

4. Role of cord factor (trehalose-6,6'-dimycolate) in allergic granuloma formation in rabbits.

5. Mycobacterial components responsible for the induction of a chronic immunological inflammatory response in rabbit lungs.

6. Relationship of BCG-induced pulmonary delayed hypersensitivity to accelerated granuloma formation in rabbit lungs: effect of cortisone acetate.