Literature DB >> 5002466

Suppression of urethan-induced lung adenomas in mice treated with trehalose-6,6-dimycolate (cord factor) and living bacillus Calmette Guérin.

A Bekierkunst, I S Levij, E Yarkoni.   

Abstract

Trehalose-6,6-dimycolate (cord factor), a glycolipid from mycobacteria, suppressed the development of urethan-induced tumors in the lungs of mice to a similar degree as living Mycobacterium bovis (strain BCG) bacilli. The inhibition was apparently due to the host cellular reaction caused locally by cord factor.

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Year:  1971        PMID： 5002466     DOI： 10.1126/science.174.4015.1240

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  24 in total

Review 1.  Cell walls of Mycobacteria and related organisms; chemistry and immunostimulant properties.

Authors:  E Lederer; A Adam; R Ciorbaru; J F Petit; J Wietzerbin
Journal:  Mol Cell Biochem       Date:  1975-05-30       Impact factor: 3.396

Review 2.  Design considerations for liposomal vaccines: influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens.

Authors:  Douglas S Watson; Aaron N Endsley; Leaf Huang
Journal:  Vaccine       Date:  2012-02-02       Impact factor: 3.641

3.  Granuloma formation in lungs of mice after intravenous administration of emulsified trehalose-6,6'-dimycolate (cord factor): reaction intensity depends on size distribution of the oil droplets.

Authors:  E Yarkoni; H J Rapp
Journal:  Infect Immun       Date:  1977-11       Impact factor: 3.441

4.  Failure of trehalose-6,6'-dimycolate (P3 or cord factor) to enhance endotoxin lethality in mice.

Authors:  E Yarkoni; M S Meltzer; H J Rapp
Journal:  Infect Immun       Date:  1976-12       Impact factor: 3.441

Review 5.  Mycobacterium.

Authors:  L Barksdale; K S Kim
Journal:  Bacteriol Rev       Date:  1977-03

6.  Granulomatous hypersensitivity to trehalose-6,6'-dimycolate (cord factor) in mice infected with BCG.

Authors:  A Bekierkunst; E Yarkoni
Journal:  Infect Immun       Date:  1973-04       Impact factor: 3.441

7.  Regression of a transplanted guinea pig hepatoma after intralesional injection of an emulsified mixture of endotoxin and mycobacterial sulfolipid.

Authors:  E Yarkoni; M B Goren; H J Rapp
Journal:  Infect Immun       Date:  1979-05       Impact factor: 3.441

8.  Proliferative responses of central and peripheral rat lymphocytes elicited by cord factor (trehalose 6,6'-dimycolate).

Authors:  F Kierszenbaum; D R Walz
Journal:  Infect Immun       Date:  1981-07       Impact factor: 3.441

9.  Nonspecific resistance against infection with Salmonella typhi and Salmonella typhimurium induced in mice by cord factor (trehalose-6,6'-dimycolate) and its analogues.

Authors:  E Yarkoni; A Bekierkunst
Journal:  Infect Immun       Date:  1976-11       Impact factor: 3.441

10.  Growth inhibition of tumour cells by a liposome-encapsulated, mycolic acid-containing glycolipid, trehalose 2,3,6'-trimycolate.

Authors:  Y Ohtsubo; M Furukawa; T Imagawa; N Sugimoto; M Ikutoh; S Nakatsugi; Y Katoh; S Shinka; Y Dohi
Journal:  Immunology       Date:  1991-11       Impact factor: 7.397
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