Literature DB >> 4555421

Correlation between hydrolysis of the -lactam bond of the cephalosporin nucleus and expulsion of the 3-substituent.

C H O'Callaghan, S M Kirby, A Morris, R E Waller, R E Duncombe.   

Abstract

The hydrolysis of two cephalosporins by three different beta-lactamases has been studied. Each enzyme caused a decrease in ultraviolet absorption, a loss of biological activity, and the release of the leaving group from the 3-position. The changes occurred at the same rate and to the same extent with each enzyme, and it is inferred that the loss of the leaving group is a consequence of, and not a prerequisite for, hydrolysis of the beta-lactam ring.

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Year:  1972        PMID： 4555421      PMCID： PMC247519          DOI： 10.1128/jb.110.3.988-991.1972

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  6 in total

1.  A comparative study of eight distinct beta-lactamases synthesized by gram-negative bacteria.

Authors:  G W Jack; M H Richmond
Journal:  J Gen Microbiol       Date:  1970-04

2.  Inhibition of beta-lactamase decomposition of cephaloridine and cephalothin by other cephalosporins.

Authors:  C H O'Callaghan; P W Muggleton; S M Kirby; D M Ryan
Journal:  Antimicrob Agents Chemother (Bethesda)       Date:  1966

3.  Effects of beta-lactamase from gram-negative organisms on cephalosporins and penicillins.

Authors:  C H O'Callaghan; P W Muggleton; G W Ross
Journal:  Antimicrob Agents Chemother (Bethesda)       Date:  1968

4.  Cephalosporinase and penicillinase activities of a beta-lactamase from Pseudomonas pyocyanea.

Authors:  L D Sabath; M Jago; E P Abraham
Journal:  Biochem J       Date:  1965-09       Impact factor: 3.857

5.  Products of aminolysis and enzymic hydrolysis of the cephalosporins.

Authors:  J M Hamilton-Miller; G G Newton; E P Abraham
Journal:  Biochem J       Date:  1970-02       Impact factor: 3.857

6.  Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate.

Authors:  C H O'Callaghan; A Morris; S M Kirby; A H Shingler
Journal:  Antimicrob Agents Chemother       Date:  1972-04       Impact factor: 5.191
  6 in total
  7 in total

1.  Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers.

Authors:  David Sevillano; María-José Giménez; Emilia Cercenado; Fabio Cafini; Amadeo Gené; Luis Alou; Francesc Marco; Luis Martínez-Martínez; Pilar Coronel; Lorenzo Aguilar
Journal:  Antimicrob Agents Chemother       Date:  2008-10-27       Impact factor: 5.191

2.  A new cephalosporin with a dual mode of action.

Authors:  C H O'Callaghan; R B Sykes; S E Staniforth
Journal:  Antimicrob Agents Chemother       Date:  1976-08       Impact factor: 5.191

Review 3.  Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes.

Authors:  P M Blumberg; J L Strominger
Journal:  Bacteriol Rev       Date:  1974-09

4.  Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.

Authors:  Shanshan Yan; Marvin J Miller; Timothy A Wencewicz; Ute Möollmann
Journal:  Medchemcomm       Date:  2010-05-05       Impact factor: 3.597

5.  Single oral dose of cefaclor for the treatment of infections with penicillinase-producing strains of Neisseria gonorrhoeae.

Authors:  T E Tupasi; O V Calubiran; C A Torres
Journal:  Br J Vener Dis       Date:  1982-06

6.  Treatment of uncomplicated gonorrhoea in women. Comparison of rosoxacin and spectinomycin.

Authors:  O V Calubiran; L B Crisologo-Vizconde; T E Tupasi; C A Torres; B M Limson
Journal:  Br J Vener Dis       Date:  1982-08

7.  Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug.

Authors:  Lindsay E Evans; Aishwarya Krishna; Yajing Ma; Thomas E Webb; Dominic C Marshall; Catherine L Tooke; James Spencer; Thomas B Clarke; Alan Armstrong; Andrew M Edwards
Journal:  J Med Chem       Date:  2019-05-01       Impact factor: 7.446
  7 in total

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