Literature DB >> 27087912

Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates.

Shanshan Yan1, Marvin J Miller1, Timothy A Wencewicz1, Ute Möollmann2.   

Abstract

Two cephalosporin-oxazolidinone conjugates were synthesized by incorporation of a carbamate linker at the 3'-position of the cephalosporin. These compounds show stability in aqueous media until specifically activated by a β-lactamase, and retain antibacterial activities profiles reflecting both the individual cephalosporin and oxazolidinone components.

Entities:  

Year:  2010        PMID： 27087912      PMCID： PMC4831628          DOI： 10.1039/C0MD00015A

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  18 in total

1.  An alternative procedure for preparation of cefdinir.

Authors:  Maritza González; Zalua Rodríguez; Blanca Tolón; Juan C Rodríguez; Hermán Velez; Bárbara Valdés; Miguel A López; Adamo Fini
Journal:  Farmaco       Date:  2003-06

2.  Syntheses and studies of quinolone-cephalosporins as potential anti-tuberculosis agents.

Authors:  Gaiying Zhao; Marvin J Miller; Scott Franzblau; Baojie Wan; Ute Möllmann
Journal:  Bioorg Med Chem Lett       Date:  2006-08-30       Impact factor: 2.823

3.  Chemistry of cephalosporin antibiotics. V. Amides and esters of cephalothin.

Authors:  R R Chauvette; E H Flynn
Journal:  J Med Chem       Date:  1966-09       Impact factor: 7.446

4.  Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone.

Authors:  H A Albrecht; G Beskid; J G Christenson; K H Deitcher; N H Georgopapadakou; D D Keith; F M Konzelmann; D L Pruess; C C Wei
Journal:  J Med Chem       Date:  1994-02-04       Impact factor: 7.446

Review 5.  Immunotherapy with Mycobacterium vaccae in the treatment of tuberculosis.

Authors:  John Stanford; Cynthia Stanford; John Grange
Journal:  Front Biosci       Date:  2004-05-01

6.  Correlation between hydrolysis of the -lactam bond of the cephalosporin nucleus and expulsion of the 3-substituent.

Authors:  C H O'Callaghan; S M Kirby; A Morris; R E Waller; R E Duncombe
Journal:  J Bacteriol       Date:  1972-06       Impact factor: 3.490

7.  Products of aminolysis and enzymic hydrolysis of the cephalosporins.

Authors:  J M Hamilton-Miller; G G Newton; E P Abraham
Journal:  Biochem J       Date:  1970-02       Impact factor: 3.857

8.  Cephalosporin derivatives of doxorubicin as prodrugs for activation by monoclonal antibody-beta-lactamase conjugates.

Authors:  V M Vrudhula; H P Svensson; P D Senter
Journal:  J Med Chem       Date:  1995-04-14       Impact factor: 7.446

9.  Aspects of the mechanism of action of some cephalosporins.

Authors:  A D Russell; R H Fountain
Journal:  J Bacteriol       Date:  1971-04       Impact factor: 3.490

10.  Immunotherapeutical potential of Mycobacterium vaccae on M. tuberculosis infection in mice.

Authors:  Li Jun Xu; Yan Yan Wang; Xiao Dong Zheng; Xiang Dong Gui; Li Feng Tao; Hai Ming Wei
Journal:  Cell Mol Immunol       Date:  2009-02       Impact factor: 11.530
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  1 in total

1.  Cephem-Pyrazinoic Acid Conjugates: Circumventing Resistance in Mycobacterium tuberculosis.

Authors:  Malcolm S Cole; Michael D Howe; Joseph A Buonomo; Sachin Sharma; Elise A Lamont; Scott I Brody; Neeraj K Mishra; Yusuke Minato; Joshua M Thiede; Anthony D Baughn; Courtney C Aldrich
Journal:  Chemistry       Date:  2022-07-27       Impact factor: 5.020
  1 in total

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