Literature DB >> 454558

Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat.

A D Rahimtula, P K Zachariah, P J O'Brien.   

Abstract

Antioxidants were found to inhibit the mixed-function oxidation of benzo(a)pyrene in several tissues of untreated and 3-methylcholanthrene-pretreated rats. The enzyme systems in the liver, kidney and stomach were much more susceptible to inhibition than those in the lung, adrenal, colon and small intestine. In all tissues except the stomach it was found that 3-methylcholanthrene pretreatment led to a decrease in inhibition of benzo(a)pyrene 3-hydroxylase activity. It is suggested that antioxidants exert their protective effect against cancer by inhibiting the formation of carcinogenic metabolites. Of the various steroids tested, only 17 beta-oestradiol and oestrone were significantly inhibitory in most tissues. Cholesterol was found to increase benzo(a)pyrene 3-hydroxylase activity in the gastrointestinal tract.

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Year:  1979        PMID： 454558      PMCID： PMC2009946          DOI： 10.1038/bjc.1979.146

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  36 in total

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Authors:  L W WATTENBERG; J L LEONG
Journal:  Cancer Res       Date:  1965-04       Impact factor: 12.701

2.  Evidence for a 2,3-epoxide as an intermediate in the microsomal metabolism of benzo[a]pyrene to 3-hydroxybenzo[a]pyrene.

Authors:  S K Yang; P P Roller; P P Fu; R G Harvey; H V Gelboin
Journal:  Biochem Biophys Res Commun       Date:  1977-08-22       Impact factor: 3.575

3.  Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants.

Authors:  A M Benson; R P Batzinger; S Y Ou; E Bueding; Y N Cha; P Talalay
Journal:  Cancer Res       Date:  1978-12       Impact factor: 12.701

4.  The effects of antioxidants on the metabolism and mutagenicity of benzo[a]pyrene in vitro.

Authors:  A D Rahimtula; P K Zachariah; P J O'Brien
Journal:  Biochem J       Date:  1977-05-15       Impact factor: 3.857

5.  The isolation of rat intestinal microsomes with stable cytochrome P-450 and their metabolism of benzo(alpha) pyrene.

Authors:  S J Stohs; R C Grafström; M D Burke; P W Moldéus; S G Orrenius
Journal:  Arch Biochem Biophys       Date:  1976-11       Impact factor: 4.013

6.  The mitigating effect of dietary antioxidants on chemically-induced carcinogenesis.

Authors:  J T Chan; H S Black
Journal:  Experientia       Date:  1978-01-15

7.  Metabolism of 7,12-dimethylbenz[a]anthracene in mouse skin homogenates analyzed with high-pressure liquid chromatography.

Authors:  J DiGiovanni; T J Slaga; D L Berry; M R Juchau
Journal:  Drug Metab Dispos       Date:  1977 May-Jun       Impact factor: 3.922

8.  Effects of butylated hydroxyanisole on the metabolism of benzo[a]pyrene by mouse liver microsomes.

Authors:  L K Lam; L W Wattenberg
Journal:  J Natl Cancer Inst       Date:  1977-02       Impact factor: 13.506

9.  The effects of antioxidants on skin tumor initiation and aryl hydrocarbon hydroxylase.

Authors:  T J Slaga; W M Bracken
Journal:  Cancer Res       Date:  1977-06       Impact factor: 12.701

10.  Selective inhibition and kinetics of enzymatic reactions leading to irreversible binding of benzo[a]pyrene to microsomal macromolecules of mouse lung.

Authors:  T W Shih; D L Hill
Journal:  Cancer Biochem Biophys       Date:  1977
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  5 in total

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Authors:  L Mankowitz; V M Castro; B Mannervik; J Rydström; J W DePierre
Journal:  Biochem J       Date:  1990-01-01       Impact factor: 3.857

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Authors:  K H Kraemer; R C Robinson; R E Tarone; M Protic-Sabljic; H V Gelboin
Journal:  Arch Dermatol Res       Date:  1984       Impact factor: 3.017

3.  Effectiveness of a Prudhoe Bay crude oil and its aliphatic, aromatic and heterocyclic fractions in inducing mortality and aryl hydrocarbon hydroxylase in chick embryo in ovo.

Authors:  P Walters; S Khan; P J O'Brien; J F Payne; A D Rahimtula
Journal:  Arch Toxicol       Date:  1987-08       Impact factor: 5.153

4.  Effects of dietary and in vitro 2(3)-t-butyl-4-hydroxy-anisole and other phenols on hepatic enzyme activities in mice.

Authors:  A D Rahimtula; B Jernström; L Dock; P Moldeus
Journal:  Br J Cancer       Date:  1982-06       Impact factor: 7.640

5.  Effect of 3, hydroxy-lup- 20(29)-en-28-oic acid on 7,12-Dimethylbenz(a) anthracene impaired cellular homeostasis in extrahepatic organs of Sprague Dawley rats.

Authors:  Pardeep Kaur; Rajbir Kaur; Rohit Arora; Saroj Arora
Journal:  J Xenobiot       Date:  2017-04-28
  5 in total

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