Literature DB >> 328015

The effects of antioxidants on the metabolism and mutagenicity of benzo[a]pyrene in vitro.

A D Rahimtula, P K Zachariah, P J O'Brien.   

Abstract

Antioxidants inhibit the rat liver microsomal mixed-function-oxidase-catalysed hydroxylation of benzo[a]pyrene. These antioxidants also decrease the formation of mutagenic products from benzo[a]pyrene as judged by the Ames bacterial-mutagenicity assay [B.N. Ames, J. McCann & E. Yamazaki (1975) Mutat. Res. 31, 347-364]. It is suggested that antioxidants exert their protective effect against cancer by inhibiting the formation of carcinogenic metabolites.

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Year:  1977        PMID： 328015      PMCID： PMC1164816          DOI： 10.1042/bj1640473

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

1.  Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

Authors:  J McCann; E Choi; E Yamasaki; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

2.  K region benzo (alpha) pyrene-4,5-oxide is conjugated by homogeneous gluthathione S-transferases.

Authors:  N Nemoto; H V Gelboin; W H Habig; J N Ketley; W B Jakoby
Journal:  Nature       Date:  1975-06-05       Impact factor: 49.962

3.  Inhibition of the mono-oxygenase system by butylated hydroxyanisole and butylated hydroxytoluene.

Authors:  C S Yang; F S Strickhart; G K Woo
Journal:  Life Sci       Date:  1974-10-15       Impact factor: 5.037

4.  Modification of the acute toxicity of mutagenic and carcinogenic chemicals in the mouse by prefeeding with antioxidants.

Authors:  R B Cumming; M F Walton
Journal:  Food Cosmet Toxicol       Date:  1973-08

5.  Antioxidants and carcinogenesis: butylated hydroxytoluene, but not diphenyl-p-phenylenediamine, inhibits cancer induction by N-2-fluorenylacetamide and by N-hydroxy-N-2-fluorenylacetamide in rats.

Authors:  B M Ulland; J H Weisburger; R S Yamamoto; E K Weisburger
Journal:  Food Cosmet Toxicol       Date:  1973-04

6.  Inhibition of NADPH-cytochrome c reductase by propyl gallate.

Authors:  M V Torrielli; T F Slater
Journal:  Biochem Pharmacol       Date:  1971-08       Impact factor: 5.858

7.  Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes.

Authors:  A Y Lu; M J Coon
Journal:  J Biol Chem       Date:  1968-03-25       Impact factor: 5.157

8.  Pharmacological implications of microsomal enzyme induction.

Authors:  A H Conney
Journal:  Pharmacol Rev       Date:  1967-09       Impact factor: 25.468

9.  Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by several sulfur-containing compounds.

Authors:  L W Wattenberg
Journal:  J Natl Cancer Inst       Date:  1974-05       Impact factor: 13.506

10.  Inhibition of hepatic mixed function oxidase activity by propyl gallate.

Authors:  C S Yang; F S Strickhart
Journal:  Biochem Pharmacol       Date:  1974-11-15       Impact factor: 5.858
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  6 in total

1.  Effect of phenolic antioxidants on the mutagenicity of aflatoxin B1.

Authors:  L A Shelef; B Chin
Journal:  Appl Environ Microbiol       Date:  1980-12       Impact factor: 4.792

2.  Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.

Authors:  A M Benson; M J Hunkeler; P Talalay
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

3.  Efficacy and Interaction of Antioxidant Supplements as Adjuvant Therapy in Cancer Treatment: A Systematic Review.

Authors:  Asuka Yasueda; Hayato Urushima; Toshinori Ito
Journal:  Integr Cancer Ther       Date:  2015-10-26       Impact factor: 3.279

4.  Anti-inflammatory agents and inducibility of hepatic drug metabolism.

Authors:  P Pappas; P Stephanou; V Vasiliou; M Marselos
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1998 Oct-Dec       Impact factor: 2.569

5.  Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat.

Authors:  A D Rahimtula; P K Zachariah; P J O'Brien
Journal:  Br J Cancer       Date:  1979-07       Impact factor: 7.640

6.  Effects of dietary and in vitro 2(3)-t-butyl-4-hydroxy-anisole and other phenols on hepatic enzyme activities in mice.

Authors:  A D Rahimtula; B Jernström; L Dock; P Moldeus
Journal:  Br J Cancer       Date:  1982-06       Impact factor: 7.640
  6 in total

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