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Literature DB >> 4531011

Effect of alkylureas on the polymerization of hemoglobin S.

D Elbaum, R L Nagel, R M Bookchin, T T Herskovits.

Abstract

Alkylureas (methyl-, ethyl-, propyl-, and butyl-) can inhibit both the gelation of deoxyhemoglobin S and red cell sickling without denaturation of the hemoglobin or intrinsic alteration of its oxygen affinity. This effect is directly proportional to the length of the alkyl chain and substantiates the importance of hydrophobic interactions in the polymerization of hemoglobin S. In addition, it opens the possibility that further systematic investigations with these compounds will help quantitate the role of hydrophobic interactions in this system so as to further our understanding of the polymerization of deoxyhemoglobin S.

Entities: Chemical

Mesh：

Substances：

Year: 1974 PMID： 4531011 PMCID： PMC433967 DOI： 10.1073/pnas.71.12.4718

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

33 in total

1. MOLECULAR ORIENTATION IN HORSE HEMOGLOBIN CRYSTALS AND SICKLED ERYTHROCYTES.

Authors: M MURAYAMA; R A OLSON; W H JENNINGS
Journal: Biochim Biophys Acta Date: 1965-01-25

2. Studies on abnormal hemoglobins. VIII. The gelling phenomenon of sickle cell hemoglobin: its biologic and diagnostic significance.

Authors: K SINGER; L SINGER
Journal: Blood Date: 1953-11 Impact factor: 22.113

Effect of alkylureas on the polymerization of hemoglobin S.

1. MOLECULAR ORIENTATION IN HORSE HEMOGLOBIN CRYSTALS AND SICKLED ERYTHROCYTES.

2. Studies on abnormal hemoglobins. VIII. The gelling phenomenon of sickle cell hemoglobin: its biologic and diagnostic significance.

3. Further studies on the oxygen equilibrium of hemoglobin.

4. Studies on the destruction of red blood cells. VIII. Molecular orientation in sickle cell hemoglobin solutions.

5. Structure of fibers of sickle cell hemoglobin.

6. Some functional properties of hemoglobin Leiden.

7. Effect of cyanate on erythrocyte deformability.

8. Dissociation of human hemoglobin by the ureas and amides. Osmotic pressure and light scattering studies.

9. Sickle hemoglobin gelation--inhibition by tris (hydroxymethyl) aminomethane and sugars.

10. Effects of pH, 2,3-diphosphoglycerate and salts on gelation of sickle cell deoxyhemoglobin.

1. Supersaturation in sickle cell hemoglobin solutions.

2. Ligand kinetics of hemoglobin S containing erythrocytes.

3. Volume, pH, and ion-content regulation in human red cells: analysis of transient behavior with an integrated model.

4. Use of citrate agar electrophoresis in evaluation of antisickling agents.

5. Determination of deoxyhemoglobin S polymer in sickle erythrocytes upon deoxygenation.

6. Inhibition of erythrocyte sickling by cystamine, a thiol reagent.