Literature DB >> 7205973

Use of citrate agar electrophoresis in evaluation of antisickling agents.

E Wilson, W P Winter.   

Abstract

Hemoglobin S (Hb S), treated with antisickling agents which interfere with gel formation, has been found to migrate on citrate agar electrophoresis in a manner similar to Hb A or Hb F. This finding suggests a rapid and inexpensive method for screening potential antisickling compounds of the types which interfere with gelation. This investigation has also led to an improved understanding of the molecular basis of citrate agar electrophoresis and to the realization that agar itself may contain a natural antisickling agent.

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Year:  1981        PMID： 7205973      PMCID： PMC2552633     

Source DB:  PubMed          Journal:  J Natl Med Assoc        ISSN： 0027-9684            Impact factor:   1.798


  7 in total

1.  A new technique for differentiation of hemoglobin.

Authors:  A R ROBINSON; M ROBSON; A P HARRISON; W W ZUELZER
Journal:  J Lab Clin Med       Date:  1957-11

2.  Differentiation of electrophoretically similar hemoglobins--such as S, D, G, and P; or A2, C, E, and O--by electrophoresis of the globin chains.

Authors:  R G Schneider
Journal:  Clin Chem       Date:  1974-09       Impact factor: 8.327

3.  Beta-chain contact sites in the haemoglobin S polymer.

Authors:  R L Nagel; J Johnson; R M Bookchin; M C Garel; J Rosa; G Schiliro; H Wajcman; D Labie; W Moo-Penn; O Castro
Journal:  Nature       Date:  1980-02-28       Impact factor: 49.962

4.  Methylisocyanate as an antisickling agent and its reaction with hemoglobin S.

Authors:  C K Lee
Journal:  J Biol Chem       Date:  1976-10-25       Impact factor: 5.157

5.  Effect of alkylureas on the polymerization of hemoglobin S.

Authors:  D Elbaum; R L Nagel; R M Bookchin; T T Herskovits
Journal:  Proc Natl Acad Sci U S A       Date:  1974-12       Impact factor: 11.205

6.  Agar derivatives for chromatography, electrophoresis and gel-bound enzymes. II. Charge-free agar.

Authors:  T Låås
Journal:  J Chromatogr       Date:  1972-04-05

7.  Inhibition of erythrocyte sickling in vitro by DL-glyceraldehyde.

Authors:  A M Nigen; J M Manning
Journal:  Proc Natl Acad Sci U S A       Date:  1977-01       Impact factor: 11.205
  7 in total
  1 in total

1.  Biological effects of short-term, high-concentration exposure to methyl isocyanate. II. Blood chemistry and hematologic evaluations.

Authors:  C M Troup; D E Dodd; E H Fowler; F R Frank
Journal:  Environ Health Perspect       Date:  1987-06       Impact factor: 9.031
  1 in total

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