Literature DB >> 3746891

Volume, pH, and ion-content regulation in human red cells: analysis of transient behavior with an integrated model.

V L Lew, R M Bookchin.   

Abstract

A basic mathematical model of human red cells is presented which integrates the charge and nonideal osmotic behavior of hemoglobin and of other impermeant cell solutes with the ion transport properties of the red cell membrane. The computing strategy was designed to predict the behavior of all measurable variables in time in ways that optimize comparison with experimentally determined behavior. The need and applications of such a model are illustrated in three separate examples covering different areas of experimentation in the physiology and pathophysiology of red cells.

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Year:  1986        PMID： 3746891     DOI： 10.1007/bf01869016

Source DB:  PubMed          Journal:  J Membr Biol        ISSN： 0022-2631            Impact factor:   1.843


  51 in total

1.  Potassium and sodium of red blood cells in sickle cell anemia.

Authors:  D C TOSTESON; E SHEA; R C DARLING
Journal:  J Clin Invest       Date:  1952-04       Impact factor: 14.808

2.  Properties of a conductive cellular chloride pathway in the skin of the toad (Bufo bufo).

Authors:  E Hviid Larsen; P Kristensen
Journal:  Acta Physiol Scand       Date:  1978-01

3.  A method for studying oxygen diffusion barrier in erythrocytes: effects of haemoglobin content and membrane cholesterol.

Authors:  K Kon; N Maeda; M Sekiya; T Shiga; T Suda
Journal:  J Physiol       Date:  1980-12       Impact factor: 5.182

4.  Measurement and stoichiometry of bumetanide-sensitive (2Na:1K:3Cl) cotransport in ferret red cells.

Authors:  A C Hall; J C Ellory
Journal:  J Membr Biol       Date:  1985       Impact factor: 1.843

5.  The electrical effects of an ionic pump.

Authors:  A S Frumento
Journal:  J Theor Biol       Date:  1965-09       Impact factor: 2.691

6.  Nature of the calcium dependent potassium leak induced by (+)-propranolol, and its possible relevance to the drug's antiarrhythmic effect.

Authors:  I M Glynn; A E Warner
Journal:  Br J Pharmacol       Date:  1972-02       Impact factor: 8.739

7.  Erythrocyte Hb-S concentration. An important factor in the low oxygen affinity of blood in sickle cell anemia.

Authors:  M Seakins; W N Gibbs; P F Milner; J F Bertles
Journal:  J Clin Invest       Date:  1973-02       Impact factor: 14.808

8.  Effect of alkylureas on the polymerization of hemoglobin S.

Authors:  D Elbaum; R L Nagel; R M Bookchin; T T Herskovits
Journal:  Proc Natl Acad Sci U S A       Date:  1974-12       Impact factor: 11.205

9.  Magnesium buffering in intact human red blood cells measured using the ionophore A23187.

Authors:  P W Flatman; V L Lew
Journal:  J Physiol       Date:  1980-08       Impact factor: 5.182

10.  Ionic and osmotic equilibria of human red blood cells treated with nystatin.

Authors:  J C Freedman; J F Hoffman
Journal:  J Gen Physiol       Date:  1979-08       Impact factor: 4.086
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  49 in total

1.  Description and analysis of metabolic connectivity and dynamics in the human red blood cell.

Authors:  Kenneth J Kauffman; John David Pajerowski; Neema Jamshidi; Bernhard O Palsson; Jeremy S Edwards
Journal:  Biophys J       Date:  2002-08       Impact factor: 4.033

2.  Shape memory of human red blood cells.

Authors:  Thomas M Fischer
Journal:  Biophys J       Date:  2004-05       Impact factor: 4.033

3.  An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum.

Authors:  Roselani I Henry; Simon A Cobbold; Richard J W Allen; Asif Khan; Rhys Hayward; Adele M Lehane; Patrick G Bray; Susan M Howitt; Giancarlo A Biagini; Kevin J Saliba; Kiaran Kirk
Journal:  J Biol Chem       Date:  2010-03-23       Impact factor: 5.157

4.  The role of potassium, potassium channels, and symporters in the apoptotic cell volume decrease: experiment and theory.

Authors:  A A Vereninov; V E Yurinskaya; A A Rubashkin
Journal:  Dokl Biol Sci       Date:  2004 Sep-Oct

5.  The hydration state of human red blood cells and their susceptibility to invasion by Plasmodium falciparum.

Authors:  Teresa Tiffert; Virgilio L Lew; Hagai Ginsburg; Miriam Krugliak; Laure Croisille; Narla Mohandas
Journal:  Blood       Date:  2005-02-22       Impact factor: 22.113

6.  Tank-tread frequency of the red cell membrane: dependence on the viscosity of the suspending medium.

Authors:  Thomas M Fischer
Journal:  Biophys J       Date:  2007-06-01       Impact factor: 4.033

7.  Apoptotic shrinkage of lymphoid cells: a model of changes in Ion flux balance.

Authors:  A A Vereninov; V E Yurinskaya; A A Rubashkin
Journal:  Dokl Biochem Biophys       Date:  2006 Nov-Dec       Impact factor: 0.788

8.  Fluctuations of the red blood cell membrane: relation to mechanical properties and lack of ATP dependence.

Authors:  James Evans; Walter Gratzer; Narla Mohandas; Kim Parker; John Sleep
Journal:  Biophys J       Date:  2008-01-30       Impact factor: 4.033

9.  Osmotic effects of protein polymerization: analysis of volume changes in sickle cell anemia red cells following deoxy-hemoglobin S polymerization.

Authors:  V L Lew; R M Bookchin
Journal:  J Membr Biol       Date:  1991-05       Impact factor: 1.843

10.  A mathematical model of the volume, pH, and ion content regulation in reticulocytes. Application to the pathophysiology of sickle cell dehydration.

Authors:  V L Lew; C J Freeman; O E Ortiz; R M Bookchin
Journal:  J Clin Invest       Date:  1991-01       Impact factor: 14.808
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