Literature DB >> 4531009

Sites of acetylation of sickle cell hemoglobin by aspirin.

M Shamsuddin, R G Mason, J M Ritchey, G R Honig, I M Klotz.   

Abstract

Aspirin acetylates a variety of sites on both the alpha and beta chains of hemoglobin S. Nevertheless, the vast majority of acetyl groups become attached to three loci: betaLys 59, betaLys 144, and alphaLys 90. These observations reveal some molecular details of this transacylation reaction and suggest interesting possibilities for its extension to other acylsalicylates with a variety of different structures.

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Year:  1974        PMID： 4531009      PMCID： PMC433962          DOI： 10.1073/pnas.71.12.4693

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Intermolecular organization of deoxygenated sickle haemoglobin determined by x-ray diffraction.

Authors:  B Magdoff-Fairchild; P H Swerdlow; J F Bertles
Journal:  Nature       Date:  1972-09-22       Impact factor: 49.962

2.  X-ray diffraction study of binding of 2,3-diphosphoglycerate to human deoxyhaemoglobin.

Authors:  A Arnone
Journal:  Nature       Date:  1972-05-19       Impact factor: 49.962

3.  Acetylation of sickle cell hemoglobin by aspirin.

Authors:  I M Klotz; J W Tam
Journal:  Proc Natl Acad Sci U S A       Date:  1973-05       Impact factor: 11.205

4.  The fine structure of sickled hemoglobin in situ.

Authors:  J G White
Journal:  Blood       Date:  1968-05       Impact factor: 22.113

5.  The removal of organic phosphates from hemoglobin.

Authors:  M Berman; R Benesch; R E Benesch
Journal:  Arch Biochem Biophys       Date:  1971-07       Impact factor: 4.013

6.  Studies on the heterogeneity of hemoglobin. 13. Chromatography of various human and animal hemoglobin types on DEAE-Sephadex.

Authors:  A M Dozy; E F Kleihauer; T H Huisman
Journal:  J Chromatogr       Date:  1968-02-20

7.  Hemoglobin interaction: modification of solid phase composition in the sickling phenomenon.

Authors:  J F Bertles; R Rabinowitz; J Döbler
Journal:  Science       Date:  1970-07-24       Impact factor: 47.728

8.  Molecular mechanism of red cell "sickling".

Authors:  M Murayama
Journal:  Science       Date:  1966-07-08       Impact factor: 47.728

9.  Potassium cyanate as an inhibitor of the sickling of erythrocytes in vitro.

Authors:  A Cerami; J M Manning
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205

10.  The physical state of hemoglobin in sickle-cell anemia erythrocytes in vivo.

Authors:  J Döbler; J F Bertles
Journal:  J Exp Med       Date:  1968-04-01       Impact factor: 14.307
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  8 in total

1.  The acetylation of hemoglobin by aspirin. In vitro and in vivo.

Authors:  K R Bridges; G J Schmidt; M Jensen; A Cerami; H F Bunn
Journal:  J Clin Invest       Date:  1975-07       Impact factor: 14.808

2.  Aspirin, protein transacetylation and inhibition of prostaglandin synthetase in the kidney.

Authors:  R J Caterson; G G Duggin; J Horvath; J Mohandas; D Tiller
Journal:  Br J Pharmacol       Date:  1978-11       Impact factor: 8.739

Review 3.  Effects of non-narcotic analgesics on the kidney.

Authors:  P Kincaid-Smith
Journal:  Drugs       Date:  1986       Impact factor: 9.546

4.  Alternative aspirins as antisickling agents: acetyl-3,5-dibromosalicylic acid.

Authors:  J A Walder; R H Zaugg; R S Iwaoka; W G Watkin; I M Klotz
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

5.  Inactivation of yeast glucose-6-P dehydrogenase by aspirin.

Authors:  P F Han; G Y Han; H C McBay; J Johnson
Journal:  Experientia       Date:  1980-10-15

Review 6.  Rational Drug Design of Peptide-Based Therapies for Sickle Cell Disease.

Authors:  Olujide O Olubiyi; Maryam O Olagunju; Birgit Strodel
Journal:  Molecules       Date:  2019-12-12       Impact factor: 4.411

7.  A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome.

Authors:  Michael H Tatham; Christian Cole; Paul Scullion; Ross Wilkie; Nicholas J Westwood; Lesley A Stark; Ronald T Hay
Journal:  Mol Cell Proteomics       Date:  2016-12-02       Impact factor: 5.911

Review 8.  Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention.

Authors:  Argentina Ornelas; Niki Zacharias-Millward; David G Menter; Jennifer S Davis; Lenard Lichtenberger; David Hawke; Ernest Hawk; Eduardo Vilar; Pratip Bhattacharya; Steven Millward
Journal:  Cancer Metastasis Rev       Date:  2017-06       Impact factor: 9.264
  8 in total

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