Literature DB >> 4527668

Antipsychotic drugs and dopamine-stimulated adenylate cyclase prepared from corpus striatum of rat brain.

M Karobath, H Leitich.   

Abstract

Antipsychotic drugs and their clinically impotent congeners were examined as inhibitors of dopamine-sensitive adenylate cyclase (EC 4.6.1.1) in cell-free membrane preparations of the caudate-putamen of rat brain. Of 12 neuroleptic drugs with reported antipsychotic efficacy, all inhibit stimulation of adenylate cyclase by 40 muM dopamine at micromolar concentrations. Among 14 other structurally related drugs that are not clinically effective as antipsychotic agents, 12 were almost ineffective while two drugs were moderate inhibitors of dopamine-sensitive adenylate cyclase.

Entities:  

Mesh：

Substances：

Year:  1974        PMID： 4527668      PMCID： PMC388584          DOI： 10.1073/pnas.71.7.2915

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Influence of neuroleptic drugs and apomorphine on dopamine-sensitive adenylate cyclase of retina.

Authors:  J H Brown; M H Makman
Journal:  J Neurochem       Date:  1973-08       Impact factor: 5.372

2.  A new simple method for separation of adenosine 3',5'-cyclic monophosphate from other nucleotides and its use in the assay of adenyl cyclase.

Authors:  J Ramachandran
Journal:  Anal Biochem       Date:  1971-09       Impact factor: 3.365

3.  Effects of certain tranquillisers on the level of homovanillic acid in the corpus striatum.

Authors:  B E Roos
Journal:  J Pharm Pharmacol       Date:  1965-12       Impact factor: 3.765

4.  Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor".

Authors:  J W Kebabian; G L Petzold; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1972-08       Impact factor: 11.205

5.  A simple, sensitive method for the assay of adenyl cyclase.

Authors:  G Krishna; B Weiss; B B Brodie
Journal:  J Pharmacol Exp Ther       Date:  1968-10       Impact factor: 4.030

6.  Dopamine antagonism and antischizophrenic potency of neuroleptic drugs.

Authors:  T J Crow; C Gillbe
Journal:  Nat New Biol       Date:  1973-09-05

7.  Uptake of (3H)-catecholamines by homogenates of rat corpus striatum and cerebral cortex: effects of amphetamine analogues.

Authors:  J E Harris; R J Baldessarini
Journal:  Neuropharmacology       Date:  1973-07       Impact factor: 5.250

8.  Accumulation and disappearance of catecholamines formed from tyrosine-14C in mouse brain; effect of some psychotropic drugs.

Authors:  H Nybäck; Z Borzecki; G Sedvall
Journal:  Eur J Pharmacol       Date:  1968-11       Impact factor: 4.432

9.  Effects of clozapine on cerebral catecholaminergic neurone systems.

Authors:  G Bartholini; W Haefely; M Jalfre; H H Keller; A Pletscher
Journal:  Br J Pharmacol       Date:  1972-12       Impact factor: 8.739

10.  Effect of drugs used in psychoses on cerebral dopamine metabolism.

Authors:  R O'Keeffe; D F Sharman; M Vogt
Journal:  Br J Pharmacol       Date:  1970-02       Impact factor: 8.739
View more
  19 in total

1.  Anticholinergic properties of antipsychotic drugs and their relation to extrapyramidal side-effects.

Authors:  A C Sayers; H R Bürki; W Ruch; H Asper
Journal:  Psychopharmacology (Berl)       Date:  1976-12-21       Impact factor: 4.530

2.  Dopamine receptor binding in the corpus striatum of mammalian brain.

Authors:  D R Burt; S J Enna; I Creese; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1975-11       Impact factor: 11.205

3.  Proteins of the synaptic membrane.

Authors:  H R Mahler
Journal:  Neurochem Res       Date:  1977-04       Impact factor: 3.996

Review 4.  A review of the discovery, pharmacological characterization, and behavioral effects of the dopamine D2-like receptor antagonist eticlopride.

Authors:  Jennifer L Martelle; Michael A Nader
Journal:  CNS Neurosci Ther       Date:  2008       Impact factor: 5.243

5.  Neuroleptic drugs block both the hyperactivity and the increase in caudate nucleus cyclic AMP concentration produced by the administration of tranylcypromine and L-dopa to rats.

Authors:  D J Heal; A R Green; M R Bloomfield; D G Grahame-Smith
Journal:  Psychopharmacology (Berl)       Date:  1978-04-28       Impact factor: 4.530

6.  ATP, cyclic AMP, and magnesium increase the affinity of rat striatal tyrosine hydroxylase for its cofactor.

Authors:  W Lovenberg; E A Bruckwick; I Hanbauer
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205

7.  Anti-dopaminergic and anti-muscarinic effects of dibenzodiazepines: relationship to drug induced Parkinsonism.

Authors:  R J Miller; C R Hiley
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976       Impact factor: 3.000

8.  Quantitative correlation of dopamine-dependent adenylate cyclase with responses to levodopa in various mice.

Authors:  L C Tang; G C Cotzias
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

9.  Opposing effects of dopaminergic to cholinergic compounds on a cerebral dopamine-activated adenylate cyclase.

Authors:  L C Tang; G C Cotzias
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

10.  Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases.

Authors:  Wolfgang Link; Julen Oyarzabal; Beatriz G Serelde; Maria Isabel Albarran; Obdulia Rabal; Antonio Cebriá; Patricia Alfonso; Jesus Fominaya; Oliver Renner; Sandra Peregrina; David Soilán; Plácido A Ceballos; Ana-Isabel Hernández; Milagros Lorenzo; Paolo Pevarello; Teresa G Granda; Guido Kurz; Amancio Carnero; James R Bischoff
Journal:  J Biol Chem       Date:  2009-08-18       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.