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Literature DB >> 4676274

Effects of clozapine on cerebral catecholaminergic neurone systems.

G Bartholini, W Haefely, M Jalfre, H H Keller, A Pletscher.

Abstract

1. Clozapine, a dibenzodiazepine derivative claimed to possess antipsychotic properties in man without producing extrapyramidal disorders, greatly increased the turnover of cerebral dopamine in the rat.2. The drug itself was virtually devoid of cataleptigenic activity in rats; however, it antagonized prochlorperazine-induced catalepsy.3. It is proposed that clozapine causes a blockade of striatal dopamine receptors which is of the surmountable type in contrast to that produced by cataleptigenic neuroleptics. In addition, clozapine may also increase the turnover of cerebral noradrenaline.

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Year: 1972 PMID： 4676274 PMCID： PMC1666362 DOI： 10.1111/j.1476-5381.1972.tb06898.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

6 in total

1. EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN.

Authors: A CARLSSON; M LINDQVIST
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1963

2. Sinistrotorsion in guinea pigs as a method of screening central anticholinergic activity.

Authors: M de JONGE; A B FUNCKE
Journal: Arch Int Pharmacodyn Ther Date: 1962-06-01

3. The fluorometric assay of catecholamines and related compounds: improvements and extensions to the hydroxyindole technique.

Authors: R Laverty; K M Taylor
Journal: Anal Biochem Date: 1968-02 Impact factor: 3.365

4. The effect of tropolone on the formation of 3,4-dihydroxyphenylacetic acid and 4-hydroxy-3-methoxyphenylacetic acid in the brain of the mouse.

Authors: G F Murphy; D Robinson; D F Sharman
Journal: Br J Pharmacol Date: 1969-05 Impact factor: 8.739

5. Effect of drugs used in psychoses on cerebral dopamine metabolism.

Authors: R O'Keeffe; D F Sharman; M Vogt
Journal: Br J Pharmacol Date: 1970-02 Impact factor: 8.739

6. The pharmacology of 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine (clozapine).

Authors: G Stille; H Lauener; E Eichenberger
Journal: Farmaco Prat Date: 1971-10

6 in total

28 in total

1. Tardive dyskinesia during and following treatment with haloperidol, haloperidol + biperiden, thioridazine, and clozapine.

Authors: J Gerlach; H Simmelsgaard
Journal: Psychopharmacology (Berl) Date: 1978-10-31 Impact factor: 4.530

2. Behavioural characterization of neuroleptic properties in the rodent.

Authors: B Costall; R J Naylor
Journal: Proc R Soc Med Date: 1977

3. A retrospective study on the long-term efficacy of clozapine in 96 schizophrenic and schizoaffective patients during a 13-year period.

Authors: L H Lindström
Journal: Psychopharmacology (Berl) Date: 1989 Impact factor: 4.530

4. Multiple neurochemical action of clozapine: a quantitative autoradiographic study of DA2, opiate and benzodiazepine receptors in the rat brain after long-term treatment.

Authors: L Giardino; L Calzà; P V Piazza; G Amato
Journal: J Neural Transm Gen Sect Date: 1991

5. On the significance of the increase in homovanillic acid (HVA) caused by antipsychotic drugs in corpus striatum and limbic forebrain.

Authors: R J Stawarz; H Hill; S E Robinson; P Setler; J V Dingell; F Sulser
Journal: Psychopharmacologia Date: 1975-08-21

9. Inhibition of 4,alpha-dimethyl-m-tyramine (H 77/77)-induced hypermotility in rats by single and repeated administration of chloropromazine, haloperidol, clozapine and thioridazine.

Authors: J Buus Lassen
Journal: Psychopharmacologia Date: 1975-07-23

Review 10. Clozapine. A review of its pharmacological properties, and therapeutic use in schizophrenia.

Authors: A Fitton; R C Heel
Journal: Drugs Date: 1990-11 Impact factor: 9.546