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Literature DB >> 4527609

A molecular model of action potentials.

Abstract

A QUANTITATIVELY CONSISTENT MODEL OF NERVE ACTIVITY IS GIVEN IN TERMS OF TWO MAIN BIOCHEMICAL CYCLES NARROWLY INTERLOCKED: an acetylcholine cycle and a calcium cycle. The activity of both cycles is controlled among other things by the electric field and various allosteric effectors. As shown by digital simulations our model accounts for the basic properties of an action potential as described by the electrophysiologists. Thus the shape, time course, and behavior under voltage clamping conditions of both sodium and potassium permeability variations are adequately reproduced.

Entities: Chemical

Mesh：

Substances：

Year: 1974 PMID： 4527609 PMCID： PMC388571 DOI： 10.1073/pnas.71.7.2858

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

10 in total

1. Ionic movements and electrical activity in giant nerve fibres.

Authors: A L HODGKIN
Journal: Proc R Soc Lond B Biol Sci Date: 1958-01-01

2. A quantitative description of membrane current and its application to conduction and excitation in nerve.

Authors: A L HODGKIN; A F HUXLEY
Journal: J Physiol Date: 1952-08 Impact factor: 5.182

3. The dual effect of membrane potential on sodium conductance in the giant axon of Loligo.

Authors: A L HODGKIN; A F HUXLEY
Journal: J Physiol Date: 1952-04 Impact factor: 5.182

4. Long-lived conformation changes induced by electric impulses in biopolymers.

Authors: E Neumann; A Katchalsky
Journal: Proc Natl Acad Sci U S A Date: 1972-04 Impact factor: 11.205

5. An attempt at an integral interpretation of nerve excitability.

Authors: E Neumann; D Nachmansohn; A Katchalsky
Journal: Proc Natl Acad Sci U S A Date: 1973-03 Impact factor: 11.205

6. On the molecular mechanism of action of scorpion neurotoxin. II. From Androctonus australis Hector.

Authors: J R Smythies; F Benington; R J Bradley; W F Bridgers; R D Morin
Journal: J Theor Biol Date: 1974-01 Impact factor: 2.691

7. Inhibition of membrane-bound acetylcholinesterase by d-tubocurarine and its reversal by bivalent cations.

Authors: P Wins; E Schoffeniels; J M Foidart
Journal: Life Sci Date: 1970-03-01 Impact factor: 5.037

8. [Contribution to the study of the allosteric properties of acetylcholinesterase].

Authors: J Gridelet; J M Foidart; P Wins
Journal: Arch Int Physiol Biochim Date: 1970-04

9. [Allosterism and permeability of cell membranes].

Authors: E Schoffeniels
Journal: Arch Int Physiol Biochim Date: 1970-04

10. THE ADENOSINE-TRIPHOSPHATASE SYSTEM RESPONSIBLE FOR CATION TRANSPORT IN ELECTRIC ORGAN: EXCLUSION OF PHOSPHOLIPIDS AS INTERMEDIATES.

Authors: I M GLYNN; C W SLAYMAN; J EICHBERG; R M DAWSON
Journal: Biochem J Date: 1965-03 Impact factor: 3.857

10 in total

7 in total

A molecular model of action potentials.

1. Ionic movements and electrical activity in giant nerve fibres.

2. A quantitative description of membrane current and its application to conduction and excitation in nerve.

3. The dual effect of membrane potential on sodium conductance in the giant axon of Loligo.

4. Long-lived conformation changes induced by electric impulses in biopolymers.

5. An attempt at an integral interpretation of nerve excitability.

6. On the molecular mechanism of action of scorpion neurotoxin. II. From Androctonus australis Hector.

7. Inhibition of membrane-bound acetylcholinesterase by d-tubocurarine and its reversal by bivalent cations.

8. [Contribution to the study of the allosteric properties of acetylcholinesterase].

9. [Allosterism and permeability of cell membranes].

10. THE ADENOSINE-TRIPHOSPHATASE SYSTEM RESPONSIBLE FOR CATION TRANSPORT IN ELECTRIC ORGAN: EXCLUSION OF PHOSPHOLIPIDS AS INTERMEDIATES.

1. Transduction of chemical into electrical energy.

2. A spike-forming model of the neural membrane.

3. Molecular model of postsynaptic potential.

4. Physical-chemical approach to the transient change in Na ion conductivity of excitable membranes.

5. Molecular events and energy changes during the action potential.

6. Protein phosphorylation and sodium conductance in nerve membrane.

7. Induced mitochondrial membrane potential for modeling solitonic conduction of electrotonic signals.