Literature DB >> 1059133

A spike-forming model of the neural membrane.

D E Wooldridge.   

Abstract

A model of the neural membrane is described, based on a set of "convertible gates" on its inner surface. The atomic arrangement of a gate is specified to be subject to modification by a set of chemical reactions, sometimes permitting sodium ions, sometimes potassium ions, sometimes neither, to have access to the transmembrane channel it guards. Reaction rate and current/voltage equations are developed, values assigned to the parameters, and computer solutions obtained. Under pulse or continuous stimulating current the model is found to generate action potential spikes closely similar in height and shape to those of real neurons. Other electrical properties are also relatively neuron-like.

Entities:  

Mesh:

Year:  1975        PMID: 1059133      PMCID: PMC433015          DOI: 10.1073/pnas.72.9.3468

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  2 in total

1.  The effect of sodium ions on the electrical activity of giant axon of the squid.

Authors:  A L HODGKIN; B KATZ
Journal:  J Physiol       Date:  1949-03-01       Impact factor: 5.182

2.  A molecular model of action potentials.

Authors:  D M Dubois; E Schoffeniels
Journal:  Proc Natl Acad Sci U S A       Date:  1974-07       Impact factor: 11.205

  2 in total
  5 in total

1.  Spike-forming model of the neural membrane: improvement in the parameter values.

Authors:  D E Wooldridge
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

2.  Spike-forming model of neural membrane: computer simulation of additional perfused axon experiments.

Authors:  D E Wooldridge
Journal:  Proc Natl Acad Sci U S A       Date:  1976-01       Impact factor: 11.205

3.  Movement of ions through fixed pores in the neural membrane.

Authors:  D E Wooldridge
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

4.  Memory neuron: synapse microchemistry for the memory component of a neuroconnective brain model.

Authors:  D E Wooldridge
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205

5.  Spike-forming model of the neural membrane: computer simulation of some perfused axon experiments.

Authors:  D E Wooldridge
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.