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Literature DB >> 1057167

Molecular model of postsynaptic potential.

Abstract

A molecular model of the excitatory postsynaptic membrane is given in terms of two biochemical cycles intimately associated: an acetylcholine cycle and a calcium cycle. The acetylcholine controls the Na ionophores while calcium ions control the tk ionophore. The two ionophores are spatially separated but interact in such a way that the variation in K conductance precedes that in Na conductance. Digital simulation shows that our model accounts quantitatively for both the evolution of excitatory postsynaptic potential and current in a variety of experimental conditions.

Entities: Chemical

Mesh：

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Year: 1975 PMID： 1057167 PMCID： PMC432623 DOI： 10.1073/pnas.72.5.1749

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

10 in total

3 in total

1. Transduction of chemical into electrical energy.

Authors: D Nachmansohn
Journal: Proc Natl Acad Sci U S A Date: 1976-01 Impact factor: 11.205

2. Calcium-binding sites as determined by electron microscope X-ray microanalysis in the electrocytes of the electric organ of Torpedo marmorata.

Authors: G Goffinet
Journal: Histochemistry Date: 1978-12-13

3. Morphology controls how hippocampal CA1 pyramidal neuron responds to uniform electric fields: a biophysical modeling study.

Authors: Guo-Sheng Yi; Jiang Wang; Bin Deng; Xi-Le Wei
Journal: Sci Rep Date: 2017-06-12 Impact factor: 4.379

3 in total

Molecular model of postsynaptic potential.

1. On the permeability of end-plate membrane during the action of transmitter.

2. An attempt at an analysis of the factors determining the time course of the end-plate current. II. Temperature.

3. Cholinergic synaptic potentials and the underlying ionic mechasims.

4. The effect of voltage on the time course of end-plate currents.

5. A molecular model of action potentials.

6. An attempt at an integral interpretation of nerve excitability.

7. Effects of procaine and d-tubocurarine on the activity of membrane bound acetylcholinesterase.

8. Inhibition of membrane-bound acetylcholinesterase by d-tubocurarine and its reversal by bivalent cations.

9. [Allosterism and permeability of cell membranes].

10. Synaptic electrogenesis in eel electroplaques.

1. Transduction of chemical into electrical energy.

2. Calcium-binding sites as determined by electron microscope X-ray microanalysis in the electrocytes of the electric organ of Torpedo marmorata.

3. Morphology controls how hippocampal CA1 pyramidal neuron responds to uniform electric fields: a biophysical modeling study.