Literature DB >> 4515623

Direct measurement of the pK values of an alkaline Bohr group in human hemoglobin.

J V Kilmartin, J J Breen, G C Roberts, C Ho.   

Abstract

Proton nuclear magnetic resonance spectra of normal and des-(his 146beta) human hemoglobin in the aromatic resonance region have been compared at different pH values. From these measurements, a pK value for histidine 146beta of 7.1 in carbonmonoxyhemoglobin and 8.0 in deoxyhemoglobin has been found. These pK values confirm the proposed role of histidine 146beta in the alkaline Bohr effect.

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Year:  1973        PMID： 4515623      PMCID： PMC433468          DOI： 10.1073/pnas.70.4.1246

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

1.  The absorption and dissociation of carbon dioxide by human blood.

Authors:  J Christiansen; C G Douglas; J S Haldane
Journal:  J Physiol       Date:  1914-07-14       Impact factor: 5.182

2.  Proton magnetic resonance studies of human hemoglobin. Histidine titrations.

Authors:  N J Greenfield; M N Williams
Journal:  Biochim Biophys Acta       Date:  1972-02-29

3.  The removal of organic phosphates from hemoglobin.

Authors:  M Berman; R Benesch; R E Benesch
Journal:  Arch Biochem Biophys       Date:  1971-07       Impact factor: 4.013

4.  Nuclear magnetic resonance titration curves of histidine ring protons. I. Influence of neighboring charged groups.

Authors:  D H Sachs; A N Schechter; J S Cohen
Journal:  J Biol Chem       Date:  1971-11       Impact factor: 5.157

5.  Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: the atomic model.

Authors:  M F Perutz; H Muirhead; J M Cox; L C Goaman
Journal:  Nature       Date:  1968-07-13       Impact factor: 49.962

6.  Three dimensional fourier synthesis of horse deoxyhaemoglobin at 2.8 Angstrom units resolution.

Authors:  W Bolton; M F Perutz
Journal:  Nature       Date:  1970-11-07       Impact factor: 49.962

7.  Three-dimensional Fourier synthesis of human deoxyhaemoglobin at 3.5 Angstrom units.

Authors:  H Muirhead; J Greer
Journal:  Nature       Date:  1970-11-07       Impact factor: 49.962

8.  Stereochemistry of cooperative effects in haemoglobin.

Authors:  M F Perutz
Journal:  Nature       Date:  1970-11-21       Impact factor: 49.962

9.  Identification of residues responsible for the alkaline Bohr effect in haemoglobin.

Authors:  M F Perutz; H Muirhead; L Mazzarella; R A Crowther; J Greer; J V Kilmartin
Journal:  Nature       Date:  1969-06-28       Impact factor: 49.962

10.  Functional nonequivalence of and hemes in human adult hemoglobin.

Authors:  T R Lindstrom; C Ho
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205
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  16 in total

1.  The interaction of some bis-arylhydroxysulphonic acids with a site of known structure in human haemoglobin.

Authors:  F F Brown; P J Goodford
Journal:  Br J Pharmacol       Date:  1977-07       Impact factor: 8.739

2.  An atomistic view on human hemoglobin carbon monoxide migration processes.

Authors:  M Fátima Lucas; Víctor Guallar
Journal:  Biophys J       Date:  2012-02-21       Impact factor: 4.033

3.  Identification of histidine-122alpha in human haemoglobin as one of the unknown alkaline Bohr groups by hydrogen--tritium exchange.

Authors:  K Nishikura
Journal:  Biochem J       Date:  1978-08-01       Impact factor: 3.857

4.  Correspondence of the pK values of oxyHb-titration states detected by resonance Raman scattering to kinetic data of ligand dissociation and association.

Authors:  R Schweitzer-Stenner; D Wedekind; W Dreybrodt
Journal:  Biophys J       Date:  1986-05       Impact factor: 4.033

5.  Some effects of post-translational N-terminal acetylation of the human embryonic zeta globin protein.

Authors:  A Scheepens; R Mould; O Hofmann; T Brittain
Journal:  Biochem J       Date:  1995-09-01       Impact factor: 3.857

6.  Proton longitudinal relaxation investigation of histidyl residues of normal human adult and sickle deoxyhemoglobin: evidence for the existence of pregelation aggregates in sickle deoxyhemoglobin solutions.

Authors:  I M Russu; C Ho
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

7.  Structure-specific model of hemoglobin cooperativity.

Authors:  A W Lee; M Karplus
Journal:  Proc Natl Acad Sci U S A       Date:  1983-12       Impact factor: 11.205

8.  The interaction of inositol hexaphosphate with methaemoglobin.

Authors:  J V Kilmartin
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857

9.  Cysteines beta93 and beta112 as probes of conformational and functional events at the human hemoglobin subunit interfaces.

Authors:  G B Vásquez; M Karavitis; X Ji; I Pechik; W S Brinigar; G L Gilliland; C Fronticelli
Journal:  Biophys J       Date:  1999-01       Impact factor: 4.033

10.  Structure of deoxyhemoglobin Cowtown [His HC3(146) beta----Leu]: origin of the alkaline Bohr effect and electrostatic interactions in hemoglobin.

Authors:  M F Perutz; G Fermi; T B Shih
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205
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