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Literature DB >> 6589624

Structure of deoxyhemoglobin Cowtown [His HC3(146) beta----Leu]: origin of the alkaline Bohr effect and electrostatic interactions in hemoglobin.

Abstract

Hemoglobin Cowtown [His HC3(146)-beta----Leu] exhibits high oxygen affinity and a halved alkaline Bohr effect. X-ray analysis shows the COOH-terminal leucine to be in equilibrium between two positions: one with the salt bridge between the terminal carboxyl and Lys C5(40)alpha intact and the leucyl side chain leaning against main chain atoms of helices F and FG and the other with the terminal salt bridge broken and the leucyl side chain touching Pro C2(37)alpha. Structural changes are confined to the immediate neighborhood of the COOH terminus, showing the halving of the alkaline Bohr effect to be due directly to the loss of the histidine, without significant contributions from changes in pK values of other ionizable groups due to structural changes elsewhere.

Entities: Chemical Disease Gene Mutation

Mesh：

Substances：
Hemoglobins, Abnormal

Year: 1984 PMID： 6589624 PMCID： PMC391574 DOI： 10.1073/pnas.81.15.4781

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

27 in total

1. Three-dimensional fourier synthesis of human deoxyhaemoglobin at 2-5 A resolution: refinement of the atomic model.

Authors: G Fermi
Journal: J Mol Biol Date: 1975-09-15 Impact factor: 5.469

2. Physicochemical studies of the relation between structure and function in hemoglobin Hiroshima (HC3 , histidine leads to aspartate).

Authors: K Imai; H B Hamilton; T Miyaji; S Shibata
Journal: Biochemistry Date: 1972-01-04 Impact factor: 3.162

3. Stereochemistry of cooperative effects in hemoglobin.

Authors: M F Perutz; L F TenEyck
Journal: Cold Spring Harb Symp Quant Biol Date: 1972

4. Direct measurement of the pK values of an alkaline Bohr group in human hemoglobin.

Authors: J V Kilmartin; J J Breen; G C Roberts; C Ho
Journal: Proc Natl Acad Sci U S A Date: 1973-04 Impact factor: 11.205

5. Three dimensional structure of haemoglobin Rainier.

Authors: J Greer; M F Perutz
Journal: Nat New Biol Date: 1971-04-28

6. Haemoglobin Hiroshima and the mechanism of the alkaline Bohr effect.

Authors: M F Perutz; P Pulsinelli; L T Eyck; J V Kilmartin; S Shibata; I Iuchi; T Miyaji; H B Hamilton
Journal: Nat New Biol Date: 1971-08-04

7. Inhibition of CO2 combination and reduction of the Bohr effect in haemoglobin chemically modified at its alpha-amino groups.

Authors: J V Kilmartin; L Rossi-Bernardi
Journal: Nature Date: 1969-06-28 Impact factor: 49.962

8. Macroscopic models for studies of electrostatic interactions in proteins: limitations and applicability.

Authors: A Warshel; S T Russell; A K Churg
Journal: Proc Natl Acad Sci U S A Date: 1984-08 Impact factor: 11.205

9. Structure and function of haemoglobin. 3. A three-dimensional fourier synthesis of human deoxyhaemoglobin at 5.5 Angstrom resolution.

Authors: H Muirhead; J M Cox; L Mazzarella; M F Perutz
Journal: J Mol Biol Date: 1967-08-28 Impact factor: 5.469

10. Hemoglobin Tarrant: alpha126(H9) Asp leads to Asn. A new hemoglobin variant in the alpha1beta1 contact region showing high oxygen affinity and reduced cooperativity.

Authors: W F Moo-Penn; D L Jue; M H Johnson; S M Wilson; B Therrell; R M Schmidt
Journal: Biochim Biophys Acta Date: 1977-02-22

7 in total

1. Detection of the heme perturbations caused by the quaternary R----T transition in oxyhemoglobin trout IV by resonance Raman scattering.

Authors: R Schweitzer-Stenner; D Wedekind; W Dreybrodt
Journal: Biophys J Date: 1989-04 Impact factor: 4.033

2. Correspondence of the pK values of oxyHb-titration states detected by resonance Raman scattering to kinetic data of ligand dissociation and association.

Authors: R Schweitzer-Stenner; D Wedekind; W Dreybrodt
Journal: Biophys J Date: 1986-05 Impact factor: 4.033

3. Basic carboxyl groups of hemoglobin S: influence of oxy-deoxy conformation on the chemical reactivity of Glu-43(beta).

Authors: M J Rao; A S Acharya
Journal: J Protein Chem Date: 1991-02