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Literature DB >> 13439111

A streptococcal enzyme that acts specifically upon diphosphopyridine nucleotide: characterization of the enzyme and its separation from streptolysin O.

A S CARLSON, A KELLNER, A W BERNHEIMER, E B FREEMAN.

Abstract

All enzyme that destroys DPN has been found in fractionated and highly concentrated streptococcal preparations that also contain streptolysin O. The enzyme-streptococcal DPNase-was shown by electrophoretic separation and by other means to be distinct from streptolysin O. It is non-dialyzable, heat-labile, and has optimal activity in the pH range 7.2 to 7.8. The enzyme has a high degree of specificity for DPN, which it splits at the nicotinamide-ribose linkage.

Entities: Chemical Species

Keywords: PHOSPHATASES; STREPTOCOCCUS/metabolism

Mesh：

Substances：

Year: 1957 PMID： 13439111 PMCID： PMC2136732 DOI： 10.1084/jem.106.1.15

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

12 in total

1. Breakdown of cozymase by a system from nervous tissue.

Authors: H McIlwain; R Rodnight
Journal: Biochem J Date: 1949 Impact factor: 3.857

2. Neurospora diphosphopyridine nucleotidase.

Authors: N O KAPLAN; S P COLOWICK; A NASON
Journal: J Biol Chem Date: 1951-08 Impact factor: 5.157

3. The reaction of pyridine nucleotide with cyanide and its analytical use.

Authors: S P COLOWICK; N O KAPLAN; M M CIOTTI
Journal: J Biol Chem Date: 1951-08 Impact factor: 5.157

4. Changes in enzymatic constitution in zinc-deficient Neurospora.

Authors: A NASON; N O KAPLAN; S P COLOWICK
Journal: J Biol Chem Date: 1951-01 Impact factor: 5.157

5. Ultraviolet absorption spectra of proteins and amino acids.

Authors: G H BEAVEN; E R HOLIDAY
Journal: Adv Protein Chem Date: 1952

6. Loss of myocardial contractility induced in isolated mammalian hearts by streptolysin O.

Authors: A W BERNHEIMER; A S CARLSON; E B FREEMAN; A KELLNER
Journal: J Exp Med Date: 1956-09-01 Impact factor: 14.307

7. PARALLELISM IN THE LETHAL AND HEMOLYTIC ACTIVITY OF THE TOXIN OF CLOSTRIDIUM SEPTICUM.

Authors: A W Bernheimer
Journal: J Exp Med Date: 1944-10-01 Impact factor: 14.307

8. Diphosphopyridine nucleotidase as an extracellular product of streptococcal growth and its possible relationship to leukotoxicity.

Authors: A W BERNHEIMER; P D LAZARIDES; A T WILSON
Journal: J Exp Med Date: 1957-07-01 Impact factor: 14.307

9. Selective inhibition by preparations of streptococcal filtrates of the oxidative metabolism of mitochondria procured from rabbit myocardium.

Authors: A W BERNHEIMER; A S CARLSON; A KELLNER
Journal: J Exp Med Date: 1956-10-01 Impact factor: 14.307

10. The use of precipitin analysis in agar for the study of human streptococcal infections. II. Ouchterlony and Oakley technics.

Authors: S P HALBERT; L SWICK; C SONN
Journal: J Exp Med Date: 1955-05-01 Impact factor: 14.307

29 in total

1. [Research on streptococcal diphosphopyridine nucleotidase. I. Partial purification and characterization of the enzyme].

Authors: K F PETERSEN; H KROEGER; H W ROTTHAUWE
Journal: Z Hyg Infektionskr Date: 1961

2. Serum inhibition of streptococcal diphosphopyridine nucleotidase in uncomplicated streptococcal pharyngitis and in rheumatic fever.

Authors: G C BERNHARD; G H STOLLERMAN
Journal: J Clin Invest Date: 1959-11 Impact factor: 14.808

8. A heat-stable nicotinamide-adenine dinucleotide glycohydrolase from Pseudomonas putida KB1. Partial purification and some properties of the enzyme and an inhibitory protein.

Authors: L H Mather; M Knight
Journal: Biochem J Date: 1972-08 Impact factor: 3.857

9. Host-parasite relationships among group A streptococci. IV. Suppression of antibody response by streptococcal pyrogenic exotoxin.

Authors: E E Hanna; D W Watson
Journal: J Bacteriol Date: 1968-01 Impact factor: 3.490

10. Properties of purified pneumococcal hemolysin.

Authors: M K Johnson
Journal: Infect Immun Date: 1972-11 Impact factor: 3.441