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Literature DB >> 4389749

D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial system.

Abstract

D-Amino acid oxidase has been identified within the granule fraction of human neutrophilic leukocytes. Leukocyte homogenates and purified kidney D-amino acid oxidase can utilize either isolated D-amino acids or some species of bacteria as substrates for the generation of hydrogen peroxide. When linked to leukocyte myeloperoxidase in vitro, purified D-amino acid oxidase constitutes a system lethal for certain bacteria. It is proposed that leukocyte D-amino acid oxidase and myeloperoxidase constitute a biochemically specific system for the recognition and killing of certain microorganisms.

Entities: Chemical Gene Species

Mesh：

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Year: 1969 PMID： 4389749 PMCID： PMC223663 DOI： 10.1073/pnas.62.3.756

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

21 in total

1. The role of the phagocyte in host-parasite interactions. 13. The direct quantitative estimation of H2O2 in phagocytizing cells.

Authors: B Paul; A J Sbarra
Journal: Biochim Biophys Acta Date: 1968-02-01

Review 2. Metabolism of the circulating leukocyte.

Authors: M J Cline
Journal: Physiol Rev Date: 1965-10 Impact factor: 37.312

3. [Electron microscopic studies on peroxidase and acid phosphatase reaction in human leukocytes (in normal and leukemic cells and on phagocytosis)].

Authors: T Enomoto; T Kitani
Journal: Nihon Ketsueki Gakkai Zasshi Date: 1966-08

4. Alpha-glucosidase activity in human leucocytes.

Authors: H E Williams
Journal: Biochim Biophys Acta Date: 1966-07-27

5. Cationic proteins of polymorphonuclear leukocyte lysosomes. II. Composition, properties, and mechanism of antibacterial action.

Authors: H I Zeya; J K Spitznagel
Journal: J Bacteriol Date: 1966-02 Impact factor: 3.490

6. Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function.

Authors: B Holmes; A R Page; R A Good
Journal: J Clin Invest Date: 1967-09 Impact factor: 14.808

7. In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood.

Authors: P G Quie; J G White; B Holmes; R A Good
Journal: J Clin Invest Date: 1967-04 Impact factor: 14.808

8. Role of the phagocyte in host-parasite interactions. XII. Hydrogen peroxide-myeloperoxidase bactericidal system in the phagocyte.

Authors: R J McRipley; A J Sbarra
Journal: J Bacteriol Date: 1967-11 Impact factor: 3.490

9. Iodination of bacteria: a bactericidal mechanism.

Authors: S J Klebanoff
Journal: J Exp Med Date: 1967-12-01 Impact factor: 14.307

10. Combined biochemical and morphological study of particulate fractions from rat liver. Analysis of preparations enriched in lysosomes or in particles containing urate oxidase, D-amino acid oxidase, and catalase.

Authors: P Baudhuin; H Beaufay; C De Duve
Journal: J Cell Biol Date: 1965-07 Impact factor: 10.539

25 in total

D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial system.

1. The role of the phagocyte in host-parasite interactions. 13. The direct quantitative estimation of H2O2 in phagocytizing cells.

Review 2. Metabolism of the circulating leukocyte.

3. [Electron microscopic studies on peroxidase and acid phosphatase reaction in human leukocytes (in normal and leukemic cells and on phagocytosis)].

4. Alpha-glucosidase activity in human leucocytes.

5. Cationic proteins of polymorphonuclear leukocyte lysosomes. II. Composition, properties, and mechanism of antibacterial action.

6. Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function.

7. In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood.

8. Role of the phagocyte in host-parasite interactions. XII. Hydrogen peroxide-myeloperoxidase bactericidal system in the phagocyte.

9. Iodination of bacteria: a bactericidal mechanism.

10. Combined biochemical and morphological study of particulate fractions from rat liver. Analysis of preparations enriched in lysosomes or in particles containing urate oxidase, D-amino acid oxidase, and catalase.

1. Protective role of D-amino acid oxidase against Staphylococcus aureus infection.

2. The mechanism of colicin E 1 action.

3. A change of heart: oxidative stress in governing muscle function?

4. Glutathione-dependent peroxidative metabolism in the alveolar macrophage.

5. Amino acid oxidase of leukocytes in relation to H 2 O 2 -mediated bacterial killing.

6. Stimulation of the hexose monophosphate shunt in human neutrophils by ascorbic acid: mechanism of action.

7. Catalase-dependent peroxidative metabolism in the alveolar macrophage during phagocytosis.

8. Studies of D-amino acid oxidase activity in human epidermis and cultured human epidermal cells.

9. Amino acid oxidase in leukocytes: evidence against a major role in phagocytosis.

10. Complete deficiency of leukocyte glucose-6-phosphate dehydrogenase with defective bactericidal activity.