Literature DB >> 4670425

Stimulation of the hexose monophosphate shunt in human neutrophils by ascorbic acid: mechanism of action.

L R DeChatelet, M R Cooper, C E McCall.   

Abstract

The addition of either ascorbic acid or dehydroascorbic acid to a suspension of polymorphonuclear leukocytes caused a dramatic increase in the resting hexose monophosphate shunt activity. A sequence of reactions involving dehydroascorbate, reduced glutathione, and reduced nicotinamide adenine dinucleotide phosphate is described to explain this stimulation. This sequence could provide an alternate method of producing H(2)O(2) and a bactericidal mechanism which is independent of myeloperoxidase.

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Year:  1972        PMID： 4670425      PMCID： PMC444158          DOI： 10.1128/AAC.1.1.12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  ENZYMATIC BASIS OF THE RESPIRATORY STIMULATION DURING PHAGOCYTOSIS.

Authors:  R H CAGAN; M L KARNOVSKY
Journal:  Nature       Date:  1964-10-17       Impact factor: 49.962

2.  'GLUCOSE 6-PHOSPHATE-DEHYDROGENASE' ACTIVITY AND THIOL CONTENT OF THYMUS NUCLEI FROM CONTROL AND X-IRRADIATED RATS.

Authors:  H DEAKIN; M G ORD; L A STOCKEN
Journal:  Biochem J       Date:  1963-11       Impact factor: 3.857

3.  Antimicrobial effect in vitro of the ascorbic acid oxidation. I. Effect on bacteria, fungi and viruses in pure cultures.

Authors:  Y ERICSSON; H LUNDBECK
Journal:  Acta Pathol Microbiol Scand       Date:  1955

4.  Killing and lysis of gram-negative bacteria through the synergistic effect of hydrogen peroxide, ascorbic acid, and lysozyme.

Authors:  T E Miller
Journal:  J Bacteriol       Date:  1969-06       Impact factor: 3.490

5.  Role of the phagocyte in host-parasite interactions. XXII. H2O2-dependent decarbosylation and deamination by myeloperoxidase and its relationship to antimicrobial activity.

Authors:  R R Strauss; B B Paul; A A Jacobs; A J Sbarra
Journal:  J Reticuloendothel Soc       Date:  1970-06

6.  A modified procedure for the determination of leukocyte alkaline phosphatase.

Authors:  L R DeChatelet; M R Cooper
Journal:  Biochem Med       Date:  1970-08

7.  Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function.

Authors:  B Holmes; A R Page; R A Good
Journal:  J Clin Invest       Date:  1967-09       Impact factor: 14.808

8.  Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection.

Authors:  R I Lehrer; M J Cline
Journal:  J Clin Invest       Date:  1969-08       Impact factor: 14.808

9.  D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial system.

Authors:  M J Cline; R I Lehrer
Journal:  Proc Natl Acad Sci U S A       Date:  1969-03       Impact factor: 11.205

10.  Myeloperoxidase-halide-hydrogen peroxide antibacterial system.

Authors:  S J Klebanoff
Journal:  J Bacteriol       Date:  1968-06       Impact factor: 3.490
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  7 in total

Review 1.  Vitamin C and immunity: an assessment of the evidence.

Authors:  W R Thomas; P G Holt
Journal:  Clin Exp Immunol       Date:  1978-05       Impact factor: 4.330

2.  Nicotinamide adenine dinucleotide glycohydrolase activity in guinea pig polymorphonuclear leukocytes.

Authors:  L R DeChatelet; C E McCall; P S Shirley
Journal:  Infect Immun       Date:  1972-09       Impact factor: 3.441

3.  Enhancement of random migration and chemotactic response of human leukocytes by ascorbic acid.

Authors:  E J Goetzl; S I Wasserman; I Gigli; K F Austen
Journal:  J Clin Invest       Date:  1974-03       Impact factor: 14.808

4.  The effect of chemotactic factors and agents which influence neutrophil movement on anaerobic glycolysis and hexose monophosphate shunt activity.

Authors:  R Anderson; A Glover; A R Rabson
Journal:  Immunology       Date:  1978-07       Impact factor: 7.397

5.  Effect of catecholamines on the bactericidal activity of polymorphonuclear leukocytes.

Authors:  D Qualliotine; L R DeChatelet; C E McCall; M R Cooper
Journal:  Infect Immun       Date:  1972-09       Impact factor: 3.441

6.  Effects of phorbol myristate acetate on the metabolism and ultrastructure of neutrophils in chronic granulomatous disease.

Authors:  J E Repine; J G White; C C Clawson; B M Holmes
Journal:  J Clin Invest       Date:  1974-07       Impact factor: 14.808

7.  Assessment of oral ascorbate in three children with chronic granulomatous disease and defective neutrophil motility over a 2-year period.

Authors:  R Anderson
Journal:  Clin Exp Immunol       Date:  1981-01       Impact factor: 4.330
  7 in total

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