Literature DB >> 43717

Effect of hexachlorobenzene on enzymes of the steroid metabolism in rat liver.

V Graef, S W Golf, G Goerz.   

Abstract

Adult female Wistar rats were fed with a diet containing 0.05% hexachlorobenzene. On the 60th day of this treatment the specific activities of NADPH: delta 4-3-oxosteroid-5 alpha-reductase and the 3-hydroxysteroid dehydrogenases in rat liver microsomes were diminished compared to control rats. The cytoplasmatic 5 beta-reduction was higher in HCB treated rats than in control rats. These alterations of the steroid metabolism lead to increased formation of 5 beta-H-steroids which are known to be inducers of the porphyrin biosynthesis.

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Year:  1979        PMID： 43717     DOI： 10.1007/bf00333618

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  17 in total

1.  [Solubilization and purification of a 3alpha-hydroxysteroid dehydrogenase in rat liver microsomes (author's transl)].

Authors:  S W Golf; V Graef; E Nowotny
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1976-01

2.  [Long time HCB exposition of rats: influence on the porphyrin excretion in the urine and on the cytochrome P-450 in the liver (author's transl)].

Authors:  G Goerz; T Krieg; K Bolsen; R Lissner
Journal:  Arch Dermatol Res       Date:  1977-08-22       Impact factor: 3.017

3.  Excessive urinary excretion of certain porphyrinogenic steroids in human acute intermittent porphyria.

Authors:  A Goldberg; M R Moore; A D Beattie; P E Hall; J McCallum; J K Grant
Journal:  Lancet       Date:  1969-01-18       Impact factor: 79.321

4.  The 5 beta-metabolites of testosterone: mode and sex-specificity of their formation in the rat liver.

Authors:  R Ghraf; H G Hoff; E R Lax; H Schriefers
Journal:  Acta Endocrinol (Copenh)       Date:  1973-07

5.  Rapid determination of urinary total porphyrins by ion exchange chromatography.

Authors:  M Doss; A Schmidt
Journal:  Z Klin Chem Klin Biochem       Date:  1971-09

6.  Isolation of a NAD:3 beta(alpha)-hydroxy-5 beta-androstane dehydrogenase from rat liver microsomes.

Authors:  S W Golf; V Graef
Journal:  J Steroid Biochem       Date:  1979-02       Impact factor: 4.292

7.  [Quantitative determination of delta-aminolevulinic acid and porphobilinogen in urine, using ion exchange chromatography columns].

Authors:  M Doss; A Schmidt
Journal:  Z Klin Chem Klin Biochem       Date:  1971-03

8.  [Studies on the mechanism of the delta-4-3-oxosteroid-5alpha-reduction in rat liver microsomes (author's transl)].

Authors:  S W Golf; V Graef; H Staudinger
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1974-12

9.  Solubilization of NADH: 4-ene-3-oxosteroid-5alpha-reductase from rat liver microsomes.

Authors:  V Graef; S W Golf; G Rempeters
Journal:  J Steroid Biochem       Date:  1978-04       Impact factor: 4.292

10.  Steroid induction of porphyrin synthesis in liver cell culture. I. Structural basis and possible physiological role in the control of heme formation.

Authors:  S Granick; A Kappas
Journal:  J Biol Chem       Date:  1967-10-25       Impact factor: 5.157
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  4 in total

1.  Occupational exposure to hexachlorocyclohexane. IV. Sex hormone alterations in HCH-exposed workers.

Authors:  S Tomczak; K Baumann; G Lehnert
Journal:  Int Arch Occup Environ Health       Date:  1981       Impact factor: 3.015

2.  Nutrition-endocrine interactions: induction of reciprocal changes in the delta 4-5 alpha-reduction of testosterone and the cytochrome P-450-dependent oxidation of estradiol by dietary macronutrients in man.

Authors:  A Kappas; K E Anderson; A H Conney; E J Pantuck; J Fishman; H L Bradlow
Journal:  Proc Natl Acad Sci U S A       Date:  1983-12       Impact factor: 11.205

3.  Further evidence for the participation of 5 beta-steroids in the development of a porphyria induced by hexachlorobenzene.

Authors:  V Graef; S W Golf; C Tyrell
Journal:  Arch Toxicol       Date:  1982-09       Impact factor: 5.153

4.  The involvement of porphyrogenic steroids in the development of experimental porphyria.

Authors:  V Graef; S W Golf; G Goerz
Journal:  Experientia       Date:  1980-09-15
  4 in total

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