Literature DB >> 6932281

The involvement of porphyrogenic steroids in the development of experimental porphyria.

V Graef, S W Golf, G Goerz.   

Abstract

Hexachlorobenzene alters the hepatic steroid metabolism, and it was suggested that a porphyria was induced by overproduction of 5 beta-H-steroids. Structurally similar chlorinated hydrocarbons (pentachlorobenzene, pentachlorophenol, 2,4,5-trichlorophenol) without porphyrogenic activity did not affect the steroid metabolism in rat liver.

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Year:  1980        PMID： 6932281     DOI： 10.1007/bf01965987

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

1.  [Studies on the mechanism of the delta-4-3-oxosteroid-5alpha-reduction in rat liver microsomes (author's transl)].

Authors:  S W Golf; V Graef; H Staudinger
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1974-12

2.  Steroid induction of porphyrin synthesis in liver cell culture. I. Structural basis and possible physiological role in the control of heme formation.

Authors:  S Granick; A Kappas
Journal:  J Biol Chem       Date:  1967-10-25       Impact factor: 5.157

3.  Induction of a deficiency of steroid delta 4-5 alpha-reductase activity in liver by a porphyrinogenic drug.

Authors:  A Kappas; H L Bradlow; D R Bickers; A P Alvares
Journal:  J Clin Invest       Date:  1977-01       Impact factor: 14.808

4.  [Hexachlorbenzene (HCB) induced porphyria in rats. Influence of HCB-metabolites on the biosynthesis of heme (author's transl)].

Authors:  G Goerz; W Vizethum; K Bolsen; T Krieg; R Lissner
Journal:  Arch Dermatol Res       Date:  1978-11-10       Impact factor: 3.017

5.  Effect of hexachlorobenzene on enzymes of the steroid metabolism in rat liver.

Authors:  V Graef; S W Golf; G Goerz
Journal:  Arch Toxicol       Date:  1979-12       Impact factor: 5.153
  5 in total

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