| Literature DB >> 4366754 |
S Pontremoli, E Melloni, A De Flora, B L Horecker.
Abstract
Fructose 1,6-bisphosphatase (EC 3.1.3.11) requires a free divalent metal and a metal chelate for optimum activity in the neutral pH range. The latter requirement can be satisfied by histidine, which appears to function as the chelating metabolite in vivo. Under fasting conditions, the concentrations of histidine in rabbit liver vary in the range required for activation of fructose bisphosphatase, and the enzyme itself is modified so that it becomes more responsive to histidine.Entities:
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Year: 1974 PMID: 4366754 PMCID: PMC388411 DOI: 10.1073/pnas.71.6.2166
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN: 0027-8424 Impact factor: 11.205