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Literature DB >> 5650365

The effects of starvation and alloxan-diabetes on the contents of citrate and other metabolic intermediates in rat liver.

Abstract

1. The content of citrate in ;freeze-clamped' livers from starved and alloxan-diabetic rats was measured by using the specific citrate assay method of Gruber & Moellering (1966). 2. The content of citrate fell progressively during a period of 48hr. starvation to reach a plateau value that is 50% of the value for livers from fed rats. Some possible explanations for the conflicting reports of changes in hepatic citrate content during starvation are discussed. 3. The hepatic contents of ATP, pyruvate, lactate, glycogen and the hexose phosphates were decreased during starvation, whereas those of acetyl-CoA and AMP were increased. 4. Acute alloxan-diabetes produced similar changes in the contents of these metabolic intermediates. 5. The effects of starvation and diabetes on the citrate and acetyl-CoA contents are discussed in relation to control of gluconeogenesis, fatty acid synthesis and the activity of citrate synthase.

Entities: Chemical Disease Gene Species

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Year: 1968 PMID： 5650365 PMCID： PMC1198678 DOI： 10.1042/bj1070411

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

25 in total

1. Regulation of glucose uptake by muscle. 7. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, on the concentrations of hexose phosphates, nucleotides and inorganic phosphate in perfused rat heart.

Authors: E A Newsholme; P J Randle
Journal: Biochem J Date: 1964-12 Impact factor: 3.857

Review 2. The cellular control of fatty acid synthesis at the enzymatic level.

Authors: F Lynen; M Matsuhashi; S Numa; E Schweizer
Journal: Biochem Soc Symp Date: 1963

3. Variations in tissue contents of coenzyme A thio esters and possible metabolic implications.

Authors: P K Tubbs; P B Garland
Journal: Biochem J Date: 1964-12 Impact factor: 3.857

4. Regulation of glucose uptake by muscles. 10. Effects of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, and of fatty acids, ketone bodies and pyruvate, on the glycerol output and concentrations of free fatty acids, long-chain fatty acyl-coenzyme A, glycerol phosphate and citrate-cycle intermediates in rat heart and diaphragm muscles.

Authors: P B Garland; P J Randle
Journal: Biochem J Date: 1964-12 Impact factor: 3.857

5. ATP controlled acetoacetate and citrate synthesis by rat liver mitochondria oxidising palmitoyl-carnitine, and the inhibition of citrate synthase by ATP.

Authors: D Shepherd; P B Garland
Journal: Biochem Biophys Res Commun Date: 1966-01-04 Impact factor: 3.575

6. Studies on the ketogenic effect of glucagon in intact rat liver.

Authors: J R Williamson; B Herczeg; H Coles; R Danish
Journal: Biochem Biophys Res Commun Date: 1966-08-12 Impact factor: 3.575

7. Effects of changes in brain metabolism on the levels of citric acid cycle intermediates.

Authors: N D Goldberg; J V Passonneau; O H Lowry
Journal: J Biol Chem Date: 1966-09-10 Impact factor: 5.157

8. [On inhibition of acetyl-CoA-carboxylase by fatty acid-coenzyme A compounds].

Authors: S Numa; E Ringelmann; F Lynen
Journal: Biochem Z Date: 1965-12-01

9. Citrate metabolism in diabetes. II. Tissue citrate content, citrate synthase and oxidation in alloxan-diabetic rat.

Authors: P K Dixit; D C DeVilliers; A Lazarow
Journal: Metabolism Date: 1967-03 Impact factor: 8.694

10. The effects of adenine nucleotides on carbohydrate metabolism in pigeon-liver homogenates.

Authors: W Gevers; H A Krebs
Journal: Biochem J Date: 1966-03 Impact factor: 3.857

39 in total

1. Glycogen phosphorylase and its converter enzymes in haemolysates of normal human subjects and of patients with type VI glycogen-storage disease. A study of phosphorylase kinase deficiency.

Authors: B Lederer; F Van Hoof; G Van den Berghe; H Hers
Journal: Biochem J Date: 1975-04 Impact factor: 3.857

2. Mass spectrometry-based microassay of (2)H and (13)C plasma glucose labeling to quantify liver metabolic fluxes in vivo.

Authors: Clinton M Hasenour; Martha L Wall; D Emerson Ridley; Curtis C Hughey; Freyja D James; David H Wasserman; Jamey D Young
Journal: Am J Physiol Endocrinol Metab Date: 2015-05-19 Impact factor: 4.310

6. Effects of starvation on intermediary metabolism in the lactating cow. A comparison with metabolic changes occurring during bovine ketosis.

Authors: G D Baird; R J Heitzman; K G Hibbitt
Journal: Biochem J Date: 1972-08 Impact factor: 3.857

10. The redistribution of carbon label by the reactions involved in glycolysis, gluconeogenesis and the tricarboxylic acid cycle in rat liver.

Authors: D F Heath
Journal: Biochem J Date: 1968-11 Impact factor: 3.857