Literature DB >> 4364174

Reversible inhibition of herpes simplex virus replication by hydroxyurea.

H S Rosenkranz, Y Becker.   

Abstract

Hydroxyurea, at a concentration of 5 x 10(-2) M, inhibits the replication of herpes simplex deoxyribonucleic acid (DNA) in the nuclei of infected cells. As a result, the synthesis of infectious virus progeny was prevented. The presence of parental viral DNA genomes in inhibited cells led to the synthesis of the viral structural peptides. The inhibitory effect of hydroxyurea was reversible; after washing the cells free from hydroxyurea, virus progeny appeared after a lag of 3 h. Upon resumption of viral DNA replication, the content of radioactive viral structural peptides gradually increased in parallel with the increase in mature virions. It is concluded that the information for the synthesis of viral structural peptides is transcribed from the parental DNA genomes.

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Year:  1973        PMID： 4364174      PMCID： PMC444409          DOI： 10.1128/AAC.3.3.325

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Electron microscopy of herpes simplex virus. 3. Effect of hydroxyurea.

Authors:  S Nii; H S Rosenkranz; C Morgan; H M Rose
Journal:  J Virol       Date:  1968-10       Impact factor: 5.103

2.  Effects of hydroxyurea on polyoma virus replication.

Authors:  A Nordenskjöld; I H Krakoff
Journal:  Cancer Res       Date:  1968-09       Impact factor: 12.701

3.  Studies on the synthesis of herpes simplex virions.

Authors:  U Olshevsky; J Levitt; Y Becker
Journal:  Virology       Date:  1967-10       Impact factor: 3.616

4.  High titre T antigen with minimal amounts of structural antigen in adenovirus-infected cells treated with hydroxyurea.

Authors:  J A Levy; R J Huebner; J Kern; R V Gilden
Journal:  Nature       Date:  1968-02-24       Impact factor: 49.962

5.  Studies with hydroxyurea. I. The reversible inhibition of bacterial DNA synthesis and the effect of hydroxyurea on the bactericidal action of streptomycin.

Authors:  H S Rosenkranz; A J Garro; J A Levy; H S Carr
Journal:  Biochim Biophys Acta       Date:  1966-03-21

6.  The effect of hydroxyurea on virus development. II. Vaccinia virus.

Authors:  H S Rosenkranz; H M Rose; C Morgan; K C Hsu
Journal:  Virology       Date:  1966-04       Impact factor: 3.616

7.  Effect of hydroxyurea on the development of African swine fever virus.

Authors:  S S Breese; C J DeBoer
Journal:  Am J Pathol       Date:  1969-04       Impact factor: 4.307

8.  Acrylamide-gel electrophorograms by mechanical fractionation: radioactive adenovirus proteins.

Authors:  J V Maizel
Journal:  Science       Date:  1966-02-25       Impact factor: 47.728

9.  Effect of hydroxyurea on virus development. I. Electron microscopic study of the effect on the development of bacteriophage T4.

Authors:  W Margaretten; C Morgan; H S Rosenkranz; H M Rose
Journal:  J Bacteriol       Date:  1966-02       Impact factor: 3.490

10.  Studies with hydroxyurea. VII. Hydroxyurea and the synthesis of functional proteins.

Authors:  H S Rosenkranz; E B Winshell; A Mednis; H S Carr; C J Ellner
Journal:  J Bacteriol       Date:  1967-10       Impact factor: 3.490
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  7 in total

1.  Effects of antimetabolites on the production of tubular structures in Vero cells infected with herpes simplex virus type 2.

Authors:  H Oda; R Mori; J Miyazono; T Iwasaka
Journal:  Arch Virol       Date:  1979       Impact factor: 2.574

2.  In vitro RNA synthesis in nuclei from herpes simplex virus infected cells: effects of ultraviolet-irradiated, defective and bromodeoxyuridine-resistant virus preparations.

Authors:  A Ben-Zeev; Y Becker
Journal:  Arch Virol       Date:  1978       Impact factor: 2.574

3.  Irreversible inhibition of herpes simplex virus replication in BSC-1 cells by zinc ions.

Authors:  Y J Gordon; Y Asher; Y Becker
Journal:  Antimicrob Agents Chemother       Date:  1975-09       Impact factor: 5.191

4.  A combined chemical-physical treatment for herpes simplex lesions in guinea pigs.

Authors:  T A Brawner; J E Senne; M Fahim
Journal:  Arch Dermatol Res       Date:  1979-05-29       Impact factor: 3.017

5.  Amazing results with hydroxyurea therapy in chronic hepatitis B: a preliminary report.

Authors:  Hessam Hassanzadeh Kashani; Aliakbar Vossoughi; Peyman Adibi; Seyed Moayed Alavian
Journal:  Hepat Mon       Date:  2010-09-01       Impact factor: 0.660

6.  Herpes simplex virus type 1 single strand DNA binding protein and helicase/primase complex disable cellular ATR signaling.

Authors:  Kareem N Mohni; Samantha Smith; Alexander R Dee; April J Schumacher; Sandra K Weller
Journal:  PLoS Pathog       Date:  2013-10-03       Impact factor: 6.823

7.  Oral disease-modifying antirheumatic drugs and immunosuppressants with antiviral potential, including SARS-CoV-2 infection: a review.

Authors:  Y C Tsai; T F Tsai
Journal:  Ther Adv Musculoskelet Dis       Date:  2020-09-03       Impact factor: 5.346
  7 in total

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