Literature DB >> 436116

The detection of various nitrosamines in the hepatocyte primary culture/DNA repair test.

G M Williams, M F Laspia.   

Abstract

Evaluation of 6 carcinogenic nitrosamines in the hepatocyte primary culture/DNA repair test revealed that all were active. Three non-carcinogenic analogs were negative. This sensitivity to nitrosamines, together with considerations concerning the metabolic capability and end point of this assay, indicates that it will be a useful addition to screening batteries that include bacterial mutagenesis assays.

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Year:  1979        PMID： 436116     DOI： 10.1016/s0304-3835(79)80034-8

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  6 in total

1.  Formation of genotoxic products from N-nitrosoheptamethyleneimine (NHMI), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) by isolated rabbit lung cells.

Authors:  J E Dahl; R Becher; M Låg; H M Schuller; E Dybing
Journal:  Cell Biol Toxicol       Date:  1990-10       Impact factor: 6.691

2.  The hepatocyte primary culture/DNA repair test using hepatocytes from several species.

Authors:  C A McQueen; G M Williams
Journal:  Cell Biol Toxicol       Date:  1987-06       Impact factor: 6.691

3.  Increased response of the rainbow trout gonad cell unscheduled DNA repair assay.

Authors:  D G Walton; A B Acton; H F Stich
Journal:  Bull Environ Contam Toxicol       Date:  1985-03       Impact factor: 2.151

4.  Membrane characteristics of adult rat liver parenchymal cells in primary monolayer culture.

Authors:  A L Tarentino; J Galivan
Journal:  In Vitro       Date:  1980-10

5.  Quantitative predictability of carcinogenicity of the covalent binding index of chemicals to DNA: comparison of the in vivo and in vitro assays.

Authors:  M Taningher; G Saccomanno; L Santi; S Grilli; S Parodi
Journal:  Environ Health Perspect       Date:  1990-03       Impact factor: 9.031

6.  Quantitative predictivity of carcinogenicity of the autoradiographic repair test (primary hepatocyte cultures) for a group of 80 chemicals belonging to different chemical classes.

Authors:  C Bolognesi; M Taningher; S Parodi; L Santi
Journal:  Environ Health Perspect       Date:  1986-12       Impact factor: 9.031
  6 in total

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