Literature DB >> 3507256

The hepatocyte primary culture/DNA repair test using hepatocytes from several species.

C A McQueen1, G M Williams.   

Abstract

The hepatocyte primary culture/DNA repair test, originally validated with rat hepatocytes, has been extended to use hepatocytes from other species including mouse, hamster, guinea pig, rabbit, monkey and human. Both qualitative and quantitative differences have been observed when chemicals are examined in the hepatocyte primary culture/DNA repair test using hepatocytes from more than one species. Examples are discussed that illustrate that the genotoxicity of a chemical can be a species-specific response and that multi-species testing permits a more complete assessment of genotoxicity.

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Year:  1987        PMID： 3507256     DOI： 10.1007/bf00058457

Source DB:  PubMed          Journal:  Cell Biol Toxicol        ISSN： 0742-2091            Impact factor:   6.691


  32 in total

1.  THE COMPARATIVE CARCINOGENICITIES OF 2-ACETYLAMINOFLUORENE AND ITS N-HYDROXY METABOLITE IN MICE, HAMSTERS, AND GUINEA PIGS.

Authors:  E C MILLER; J A MILLER; M ENOMOTO
Journal:  Cancer Res       Date:  1964-12       Impact factor: 12.701

Review 2.  The use of cells from rat, mouse, hamster, and rabbit in the hepatocyte primary culture/DNA-repair test.

Authors:  C A McQueen; G M Williams
Journal:  Ann N Y Acad Sci       Date:  1983       Impact factor: 5.691

3.  Genotoxicity of cycasin in the hepatocyte primary culture/DNA repair test supplemented with beta-glucosidase.

Authors:  G M Williams; M F Laspia; H Mori; I Hirono
Journal:  Cancer Lett       Date:  1981-05       Impact factor: 8.679

4.  Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures.

Authors:  G M Williams
Journal:  Cancer Res       Date:  1977-06       Impact factor: 12.701

5.  Long-term and short-term screening assays for carcinogens: a critical appraisal.

Authors: 
Journal:  IARC Monogr Eval Carcinog Risk Chem Hum Suppl       Date:  1980

6.  The hepatocyte primary culture/DNA repair assay using mouse or hamster hepatocytes.

Authors:  C A McQueen; D M Kreiser; G M Williams
Journal:  Environ Mutagen       Date:  1983

7.  Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes.

Authors:  H Mori; K Kawai; F Ohbayashi; T Kuniyasu; M Yamazaki; T Hamasaki; G M Williams
Journal:  Cancer Res       Date:  1984-07       Impact factor: 12.701

8.  Induction of DNA repair in human and rat hepatocytes by 1,6-dinitropyrene.

Authors:  B E Butterworth; L L Earle; S Strom; R Jirtle; G Michalopoulos
Journal:  Mutat Res       Date:  1983-10       Impact factor: 2.433

9.  Comparison of 7 azo dyes and their azo reduction products in the rat and hamster hepatocyte primary culture/DNA-repair assays.

Authors:  D J Kornbrust; T R Barfknecht
Journal:  Mutat Res       Date:  1984-06       Impact factor: 2.433

10.  Genotoxicity of the antihypertensive drugs hydralazine and dihydralazine.

Authors:  G M Williams; G Mazue; C A McQueen; T Shimada
Journal:  Science       Date:  1980-10-17       Impact factor: 47.728
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  2 in total

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Authors:  Xue-Zhong Ma; Agata Bartczak; Jianhua Zhang; Wei He; Itay Shalev; David Smil; Limin Chen; Jim Phillips; Jordan J Feld; Nazia Selzner; Gary Levy; Ian McGilvray
Journal:  J Virol       Date:  2014-03-19       Impact factor: 5.103

Review 2.  Dehydropyrrolizidine Alkaloid Toxicity, Cytotoxicity, and Carcinogenicity.

Authors:  Bryan L Stegelmeier; Steven M Colegate; Ammon W Brown
Journal:  Toxins (Basel)       Date:  2016-11-29       Impact factor: 4.546
  2 in total

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