Literature DB >> 4333989

Inhibition of release of dopamine- -hydroxylase and norepinephrine from sympathetic nerves by colchicine, vinblastine, or cytochalasin-B (hypogastric nerve stimulation-exocytosis-microtubules-microfilaments-guinea pig).

N B Thoa, G F Wooten, J Axelrod, I J Kopin.   

Abstract

Stimulation of the hypogastric nerve to the guinea pig vas deferens in the presence of phenoxybenzamine produced an enhanced release of both dopamine-beta-hydroxylase (EC 1.14.2.1) and norepinephrine. Addition of colchicine, vinblastine, or cytochalasin-B to the incubation medium caused an almost complete inhibition of release of both the amine and the enzyme. Colchicine and cytochalasin-B produced a blocking effect but did not, however, modify the ratio of dopamine-beta-hydroxylase to norepinephrine recovered in the bath fluid. The findings indicate that norepinephrine and dopamine-beta-hydroxylase are released from sympathetic nerve terminals by exocytosis and that this process is dependent upon the integrity of both microtubules and microfilaments.

Entities:  

Mesh：

Substances：

Year:  1972        PMID： 4333989      PMCID： PMC426493          DOI： 10.1073/pnas.69.2.520

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Electron microscope study of the excretion of cathecol-containing droplets in the adrenal medulla.

Authors:  E DE ROBERTIS; A VAZ FERREIRA
Journal:  Exp Cell Res       Date:  1957-06       Impact factor: 3.905

2.  Histamine release from rat peritoneal mast cells: inhibition by colchicine and potentiation by deuterium oxide.

Authors:  E Gillespie; R J Levine; S E Malawista
Journal:  J Pharmacol Exp Ther       Date:  1968-11       Impact factor: 4.030

3.  New hypothesis of insulin secretion.

Authors:  P E Lacy; S L Howell; D A Young; C J Fink
Journal:  Nature       Date:  1968-09-14       Impact factor: 49.962

4.  Effect of colchicine on transport of amine storage granules in sympathetic nerves of rat.

Authors:  A Dahlström
Journal:  Eur J Pharmacol       Date:  1968-12       Impact factor: 4.432

5.  Properties of colchicine binding protein from chick embryo brain. Interactions with vinca alkaloids and podophyllotoxin.

Authors:  L Wilson
Journal:  Biochemistry       Date:  1970-12-08       Impact factor: 3.162

6.  Microfilaments in cellular and developmental processes.

Authors:  N K Wessells; B S Spooner; J F Ash; M O Bradley; M A Luduena; E L Taylor; J T Wrenn; K Yamada
Journal:  Science       Date:  1971-01-15       Impact factor: 47.728

7.  Effects of cytochalasins on mammalian cells.

Authors:  S B Carter
Journal:  Nature       Date:  1967-01-21       Impact factor: 49.962

8.  Possible role of microtubules in thyroid secretion.

Authors:  J A Williams; J Wolff
Journal:  Proc Natl Acad Sci U S A       Date:  1970-12       Impact factor: 11.205

9.  Studies on the translocation of noradrenaline-containing vesicles in post-ganglionic sympathetic neurones in vitro. Inhibition of movement by colchicine and vinblastine and evidence for the involvement of axonal microtubules.

Authors:  P Banks; D Mayor; M Mitchell; D Tomlinson
Journal:  J Physiol       Date:  1971-08       Impact factor: 5.182

10.  Effects of mitotic spindle inhibitors on neurotubules and neurofilaments in anterior horn cells.

Authors:  H Wisniewski; M L Shelanski; R D Terry
Journal:  J Cell Biol       Date:  1968-07       Impact factor: 10.539
View more
  25 in total

1.  The in vitro effects of vinblastine and vincristine on the responses of the guinea-pig vas deferens to nerve stimulation.

Authors:  T Bennett
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

2.  Further immunofluorescence-microscopic evidence for myosin in various peripheral nerves.

Authors:  K Unsicker; D Drenckhahn; U Grüschel-Stewart
Journal:  Cell Tissue Res       Date:  1978-04-17       Impact factor: 5.249

3.  Cytochalasin B: inhibition of glucose-induced insulin release from isolated rat pancreatic islets.

Authors:  P Schauder; H Frerichs
Journal:  Diabetologia       Date:  1974-02       Impact factor: 10.122

4.  Effects of colchicine and cytochalasin B on the release of 3 H-norepinephrine from guinea-pig atria evoked by high potassium, nicotine and tyramine.

Authors:  M Sorimachi; F Oesch; H Thoenen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

5.  Muscle-like contractile proteins and tubulin in synaptosomes.

Authors:  A L Blitz; R E Fine
Journal:  Proc Natl Acad Sci U S A       Date:  1974-11       Impact factor: 11.205

6.  Proceedings: The in vitro effects of vinblastine on the nerve-mediated responses of the guinea-pig vas deferens.

Authors:  T Bennett; P A Kemp
Journal:  Br J Pharmacol       Date:  1974-03       Impact factor: 8.739

Review 7.  A molecular basis for learning and memory.

Authors:  E M Kosower
Journal:  Proc Natl Acad Sci U S A       Date:  1972-11       Impact factor: 11.205

8.  Colchicine effects on neurosecretory neurons and other hypothalamic and hypophysial cells, with special reference to changes in the cytoplasmic membranes.

Authors:  C Hindelang-Gertner; M E Stoeckel; A Porte; F Stutinsky
Journal:  Cell Tissue Res       Date:  1976-07-20       Impact factor: 5.249

9.  Investigations into the biochemical basis of neuromodulation by 2-phenylethylamine: effect on microtubule protein.

Authors:  M E Knight; J Harris
Journal:  Neurochem Res       Date:  1993-12       Impact factor: 3.996

10.  Neurotoxicity of acrylamide and related compounds in rats. Effects on rotarod performance, morphology of nerves and neurotubulin.

Authors:  H Tanii; K Hashimoto
Journal:  Arch Toxicol       Date:  1983-11       Impact factor: 5.153
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.