Literature DB >> 167294

The in vitro effects of vinblastine and vincristine on the responses of the guinea-pig vas deferens to nerve stimulation.

T Bennett.   

Abstract

1. Neither vinblastine nor vincristine (1x10-4M) appeared to cause a specific blockade of transmission through the guinea-pig hypogastric ganglion, since responses to preganglionic nerve trunk stimulation were lost no sooner than responses to postganglionic nerve trunk stimulation. 2. The responses to postganglionic nerve trunk stimulation were blocked by vinblastine or vincristine at a time when responses to stimulation of intramural nerve fibres were little affected. 3. The results do not support the suggestion that inhibition of the exocytotic release of transmitter is responsible for the early in vitro effects of these drugs.

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Year:  1975        PMID： 167294     DOI： 10.1007/bf00500042

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  9 in total

1.  The effects of intravenous injections of vinblastine or vincristine on the responses of the rat heart to nerve stimulation and to drugs.

Authors:  T Bennett; S M Gardiner
Journal:  Br J Pharmacol       Date:  1975-03       Impact factor: 8.739

Review 2.  Pharmacological aspects of peripheral noradrenergic transmission.

Authors:  W P de Potter; I W Chubb; A F de Schaepdryver
Journal:  Arch Int Pharmacodyn Ther       Date:  1972-04

3.  Effects of colchicine and cytochalasin B on the release of 3 H-norepinephrine from guinea-pig atria evoked by high potassium, nicotine and tyramine.

Authors:  M Sorimachi; F Oesch; H Thoenen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

4.  Inhibition by colchicine and by vinblastine of acetylcholine-induced catecholamine release from the adrenal gland: an anticholinergic action, not an effect upon microtubules.

Authors:  J M Trifaró; B Collier; A Lastowecka; D Stern
Journal:  Mol Pharmacol       Date:  1972-03       Impact factor: 4.436

5.  The guinea-pig isolated vas deferens: a method for increasing sensitivity to drugs.

Authors:  N B Thoa; G D Maengwyn-Davies
Journal:  J Pharm Pharmacol       Date:  1968-11       Impact factor: 3.765

6.  Proceedings: The in vitro effects of vinblastine on the nerve-mediated responses of the guinea-pig vas deferens.

Authors:  T Bennett; P A Kemp
Journal:  Br J Pharmacol       Date:  1974-03       Impact factor: 8.739

7.  Interaction of drugs with microtubule proteins.

Authors:  L Wilson; J R Bamburg; S B Mizel; L M Grisham; K M Creswell
Journal:  Fed Proc       Date:  1974-02

8.  Vinblastine and vincristine: a study of their action on tissue concentrations of epinephrine, norephinephrine and acetylcholine.

Authors:  D L Cheney; I Hanin; R Massarelli; M Trabucchi; E Costa
Journal:  Neuropharmacology       Date:  1973-03       Impact factor: 5.250

9.  Inhibition of release of dopamine- -hydroxylase and norepinephrine from sympathetic nerves by colchicine, vinblastine, or cytochalasin-B (hypogastric nerve stimulation-exocytosis-microtubules-microfilaments-guinea pig).

Authors:  N B Thoa; G F Wooten; J Axelrod; I J Kopin
Journal:  Proc Natl Acad Sci U S A       Date:  1972-02       Impact factor: 11.205
  9 in total
  1 in total

1.  An ultrastructural examination of the action of vinblastine on microtubules, neurofilaments and muscle filaments in vitro.

Authors:  D R Tomlinson; T Bennett
Journal:  Cell Tissue Res       Date:  1976-02-25       Impact factor: 5.249
  1 in total

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