Literature DB >> 4333977

Acetoxycycloheximide-induced transient amnesia: protective effects of adrenergic stimulants.

R G Serota, R B Roberts, L B Flexner.   

Abstract

It has previously been shown that rats trained 5 hr after intracerebral injection of acetoxycycloheximide show a transient amnesia at 24 hr after training. We have tested the possibility that adrenergic stimulants might provide protection from the amnesia. Metaraminol, given either before or after training or before testing, prevents the drug-induced amnesia. D-Amphetamine, injected soon after training, also prevents the amnesia. A model is presented to explain the drug-induced amnesia in terms of both the assumed effect of acetoxycycloheximide on the adrenergic system and prevention of the amnesia by metaraminol and D-amphetamine.

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Year:  1972        PMID： 4333977      PMCID： PMC426453          DOI： 10.1073/pnas.69.2.340

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  12 in total

1.  Effect of acetoxycycloheximide on learning and memory of a light-dark discrimination.

Authors:  H D Cohen; S H Barondes
Journal:  Nature       Date:  1968-04-20       Impact factor: 49.962

2.  Reversal of the reserpine-induced suppression of the conditioned avoidance response by L-dopa: correlation of behavioral and biochemical differences in two strains of mice.

Authors:  L S Seiden; D D Peterson
Journal:  J Pharmacol Exp Ther       Date:  1968-02       Impact factor: 4.030

3.  Effects of hydrocortisone and cycloheximide on blood-brain barrier function in the rat.

Authors:  C Angel; M L Burkett
Journal:  Dis Nerv Syst       Date:  1971-01

4.  Delayed and sustained effect of acetoxycycloheximide on memory in mice.

Authors:  S H Barondes; H D Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1967-07       Impact factor: 11.205

5.  Arousal and the conversion of "short-term" to "long-term" memory.

Authors:  S H Barondes; H D Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1968-11       Impact factor: 11.205

6.  Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice.

Authors:  L B Flexner; J B Flexner
Journal:  Proc Natl Acad Sci U S A       Date:  1966-02       Impact factor: 11.205

7.  Stages of memory in mice treated with acetoxycycloheximide before or immediately after learning.

Authors:  L B Flexner; J B Flexner; R B Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  1966-08       Impact factor: 11.205

8.  Amnesia produced by electroconvulsive shock or cycloheximide: conditions for recovery.

Authors:  D Quartermain; B S McEwen; E C Azmitia
Journal:  Science       Date:  1970-08-14       Impact factor: 47.728

9.  Memory in mice analyzed with antibiotics. Antibiotics are useful to study stages of memory and to indicate molecular events which sustain memory.

Authors:  L B Flexner; J B Flexner; R B Roberts
Journal:  Science       Date:  1967-03-17       Impact factor: 47.728

10.  Some evidence for the involvement of adrenergic sites in the memory trace.

Authors:  R B Roberts; J B Flexner; L B Flexner
Journal:  Proc Natl Acad Sci U S A       Date:  1970-06       Impact factor: 11.205
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  13 in total

Review 1.  An hypothesis on the role of glucose in the mechanism of action of cognitive enhancers.

Authors:  G L Wenk
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

Review 2.  Protein synthesis inhibition and memory: formation vs amnesia.

Authors:  Paul E Gold
Journal:  Neurobiol Learn Mem       Date:  2007-12-03       Impact factor: 2.877

Review 3.  The role of protein synthesis in memory consolidation: progress amid decades of debate.

Authors:  Pepe J Hernandez; Ted Abel
Journal:  Neurobiol Learn Mem       Date:  2007-11-28       Impact factor: 2.877

4.  The effects of emetine hydrochloride on brain protein synthesis and on dark avoidance response in the goldfish.

Authors:  S Ohi
Journal:  Experientia       Date:  1977-09-15

Review 5.  Role of RNA and protein in memory storage: a review.

Authors:  L L Uphouse; J W MacInnes; K Schlesinger
Journal:  Behav Genet       Date:  1974-03       Impact factor: 2.805

6.  Lidocaine attenuates anisomycin-induced amnesia and release of norepinephrine in the amygdala.

Authors:  Renee N Sadowski; Clint E Canal; Paul E Gold
Journal:  Neurobiol Learn Mem       Date:  2011-03-29       Impact factor: 2.877

7.  Improvement of shuttle-box avoidance by combinations of orotic acid and central stimulants.

Authors:  D Yonkov; W Wetzel; H Matthies; K Roussinov
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

8.  Cycloheximide and acetoxycycloheximide: inhibition of tyrosine hydroxylase activity and amnestic effects.

Authors:  L B Flexner; R G Serota; R H Goodman
Journal:  Proc Natl Acad Sci U S A       Date:  1973-02       Impact factor: 11.205

9.  Effects of nefiracetam, DM-9384 on amnesia and decrease in choline acetyltransferase activity induced by cycloheximide.

Authors:  T Shiotani; K Tohyama; K Murase; S Ishihara; T Kameyama; T Yamasaki; S Hatanaka; H Kojima; Y Takasu; T Nabeshima
Journal:  J Neural Transm Gen Sect       Date:  1992

10.  Studies on memory: inhibitors of protein synthesis also inhibit catecholamine synthesis.

Authors:  L B Flexner; R H Goodman
Journal:  Proc Natl Acad Sci U S A       Date:  1975-11       Impact factor: 11.205
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