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Literature DB >> 1463591

Effects of nefiracetam, DM-9384 on amnesia and decrease in choline acetyltransferase activity induced by cycloheximide.

T Shiotani¹, K Tohyama, K Murase, S Ishihara, T Kameyama, T Yamasaki, S Hatanaka, H Kojima, Y Takasu, T Nabeshima.

Abstract

The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1992 PMID： 1463591 DOI： 10.1007/bf01250792

Source DB: PubMed Journal: J Neural Transm Gen Sect

29 in total

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Authors: M E Hall; K Schlesinger; E Stamm
Journal: Pharmacol Biochem Behav Date: 1976-03 Impact factor: 3.533

2. A rapid radiochemical method for the determination of choline acetyltransferase.

Authors: F Fonnum
Journal: J Neurochem Date: 1975-02 Impact factor: 5.372

3. The effect of stimulants, depressants, and protein synthesis- inhibition on retention.

Authors: J F Flood; M E Jarvik; E L Bennett; A E Orme; M R Rosenzweig
Journal: Behav Biol Date: 1977-06

4. Modifications of brain glutamate decarboxylase activity by pyridoxal phosphate-gamma-glutamyl hydrazone.

Authors: R Tapia; M Pérez de la Mora; G H Massieu
Journal: Biochem Pharmacol Date: 1967-07-07 Impact factor: 5.858

5. A post-mortem study of the cholinergic and GABA systems in senile dementia.

Authors: M N Rossor; N J Garrett; A L Johnson; C Q Mountjoy; M Roth; L L Iversen
Journal: Brain Date: 1982-06 Impact factor: 13.501

6. On the interaction between nicotine and cycloheximide.

Authors: H Sershen; M E Reith; A Lajtha
Journal: Brain Res Date: 1982-11-11 Impact factor: 3.252

7. Effects of DM-9384, a cyclic derivative of GABA, on amnesia and decreases in GABAA and muscarinic receptors induced by cycloheximide.

Authors: T Nabeshima; K Tohyama; K Murase; S Ishihara; T Kameyama; T Yamasaki; S Hatanaka; H Kojima; T Sakurai; Y Takasu
Journal: J Pharmacol Exp Ther Date: 1991-04 Impact factor: 4.030

3. Effects of nefiracetam on deficits in active avoidance response and hippocampal cholinergic and monoaminergic dysfunctions induced by AF64A in mice.

Authors: E Abe; S Murai; H Saito; Y Masuda; Y Takasu; T Shiotani; H Tachizawa; T Itoh
Journal: J Neural Transm Gen Sect Date: 1994

3 in total

Effects of nefiracetam, DM-9384 on amnesia and decrease in choline acetyltransferase activity induced by cycloheximide.

1. Prevention of memory loss following puromycin treatment.

2. A rapid radiochemical method for the determination of choline acetyltransferase.

3. The effect of stimulants, depressants, and protein synthesis- inhibition on retention.

4. Modifications of brain glutamate decarboxylase activity by pyridoxal phosphate-gamma-glutamyl hydrazone.

5. A post-mortem study of the cholinergic and GABA systems in senile dementia.

6. On the interaction between nicotine and cycloheximide.

7. Effects of DM-9384, a cyclic derivative of GABA, on amnesia and decreases in GABAA and muscarinic receptors induced by cycloheximide.

8. Effects of DM-9384 in a model of amnesia based on animals with GABAergic neuronal dysfunctions.

9. Effect of intraventricular gamma-aminobutyric acid (GABA) on discrimination learning in rats.

10. Role of cholinergic and GABAergic neuronal systems in cycloheximide-induced amnesia in mice.

1. Electric field distribution of event-related potentials in stroke patients.

2. Improvement by nefiracetam of beta-amyloid-(1-42)-induced learning and memory impairments in rats.

3. Effects of nefiracetam on deficits in active avoidance response and hippocampal cholinergic and monoaminergic dysfunctions induced by AF64A in mice.