Literature DB >> 6114508

Improvement of shuttle-box avoidance by combinations of orotic acid and central stimulants.

D Yonkov, W Wetzel, H Matthies, K Roussinov.   

Abstract

The effect of orotic acid and central stimulants on retention of shuttle-box avoidance was investigated in rats. Orotic acid (100 mg/kg) was injected 30 min before training; caffeine (20mg/kg), strychnine (1 mg/kg), or methylphenidate (10 mg/kg) were injected immediately after training. When given alone, these drugs improved avoidance retention when tested 24 h after training. However, improvement of retention was much more evident when orotic acid was given in combination with a stimulant. The data are discussed in relation to the role of macromolecule synthesis and arousal in memory formation.

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Year:  1981        PMID： 6114508     DOI： 10.1007/bf00426475

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  21 in total

1.  Effects of d-amphetamine and strychnine on cycloheximide- and diethyldithiocarbamate-induced amnesia in mice.

Authors:  E E Quinton; A S Bloom
Journal:  J Comp Physiol Psychol       Date:  1977-12

2.  The effect of stimulants, depressants, and protein synthesis- inhibition on retention.

Authors:  J F Flood; M E Jarvik; E L Bennett; A E Orme; M R Rosenzweig
Journal:  Behav Biol       Date:  1977-06

3.  Effects of amphetamine on short-term, protein-independent, memory in day-old chickens.

Authors:  M E Gibbs
Journal:  Pharmacol Biochem Behav       Date:  1976-03       Impact factor: 3.533

Review 4.  Drug facilitation of learning and memory.

Authors:  J L McGaugh
Journal:  Annu Rev Pharmacol       Date:  1973       Impact factor: 13.820

5.  Suppression of uridine monophosphate-induced improvement in long-term storage by cycloheximide.

Authors:  T Ott; H Matthies
Journal:  Psychopharmacologia       Date:  1973

6.  Some effects of RNA precursors on development and maintenance of long-term memory: hippocampal and cortical pre- and post-training application of RNA precursors.

Authors:  T Ott; H Matthies
Journal:  Psychopharmacologia       Date:  1973-01-01

Review 7.  Effects of drugs on learning and memory.

Authors:  J L McGaugh; L F Petrinovich
Journal:  Int Rev Neurobiol       Date:  1965       Impact factor: 3.230

8.  [The effect of orotic acid on the extinction of a conditioned escape reaction in the rat].

Authors:  H Matthies; W Lietz
Journal:  Acta Biol Med Ger       Date:  1967

9.  Cholinergic mechanisms in the learning and memory facilitating effect of the central stimulants. III. Influence of the anticholinergic agents on the learning and memory facilitating effect of amphetamine.

Authors:  D I Yonkov; K S Roussinov
Journal:  Acta Physiol Pharmacol Bulg       Date:  1978

10.  Cholinergic mechanisms in the learning and memory facilitating effects of central stimulants. IV. Influence of anticholinergic agents on the memory-facilitating effect of echinopsine and Centedrine (methylphenidate).

Authors:  D Yonkov; K Roussinov
Journal:  Acta Physiol Pharmacol Bulg       Date:  1979
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  2 in total

1.  Memory enhancement: supra-additive effect of subcutaneous cholinergic drug combinations in mice.

Authors:  J F Flood; G E Smith; A Cherkin
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

2.  Effect of the memory-improving substance methylglucamine orotate on paradoxical sleep in rats.

Authors:  W Wetzel; T Ott; H K Matthies; H Matthies
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530
  2 in total

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