Literature DB >> 4332017

Mechanism of action of bacitracin: complexation with metal ion and C 55 -isoprenyl pyrophosphate.

K J Stone, J L Strominger.   

Abstract

The inhibition by bacitracin of the enzymatic dephosphorylation of C(55)-isoprenyl pyrophosphate is abolished by the addition of chelating agents. If, however, the chelating agent is added after a preincubation of bacitracin with a divalent cation and the lipid substrate, then its addition has little effect, indicating that bacitracin, metal ion, and C(55)-isoprenyl pyrophosphate form a complex. Various divalent cations can participate in complex formation, but monovalent cations are ineffective. A direct demonstration of the formation of a complex between the C(55)-isoprenyl pyrophosphate and bacitracin in the presence of metal ions was obtained. Molecular models that show one possible conformation for a complex between bacitracin and the C(55)-isoprenyl pyrophosphate, in which the metal ion acts as a bridge between the two compounds, are presented.

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Year:  1971        PMID： 4332017      PMCID： PMC389626          DOI： 10.1073/pnas.68.12.3223

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  10 in total

1.  Measurement of protein-binding phenomena by gel filtration.

Authors:  J P HUMMEL; W J DREYER
Journal:  Biochim Biophys Acta       Date:  1962-10-08

2.  Requirement of divalent metal ions for bacitracin activity.

Authors:  R H ADLER; J E SNOKE
Journal:  J Bacteriol       Date:  1962-06       Impact factor: 3.490

3.  The incorporation of amino acids into the cell-wall mucopeptide of staphylococci and the effect of antibiotics on the process.

Authors:  J MANDELSTAM; H J ROGERS
Journal:  Biochem J       Date:  1959-08       Impact factor: 3.857

4.  Bacitracin: an inhibitor of the dephosphorylation of lipid pyrophosphate, an intermediate in the biosynthesis of the peptidoglycan of bacterial cell walls.

Authors:  G Siewert; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1967-03       Impact factor: 11.205

5.  Biosynthesis of the peptidoglycan of bacterial cell walls. XIX. Isoprenoid alcohol phosphokinase.

Authors:  Y Higashi; G Siewert; J L Strominger
Journal:  J Biol Chem       Date:  1970-07-25       Impact factor: 5.157

6.  Binding sites for zinc (II) in bacitracin.

Authors:  N W Cornell; D G Guiney
Journal:  Biochem Biophys Res Commun       Date:  1970-08-11       Impact factor: 3.575

7.  Bacitracin A. Isolation by counter double-current distribution and characterization.

Authors:  L C Craig; W F Phillips; M Burachik
Journal:  Biochemistry       Date:  1969-06       Impact factor: 3.162

8.  Biosythesis of the peptidoglycan of bacterial cell walls. II. Phospholipid carriers in the reaction sequence.

Authors:  J S Anderson; M Matsuhashi; M A Haskin; J L Strominger
Journal:  J Biol Chem       Date:  1967-07-10       Impact factor: 5.157

9.  Biosynthesis of the peptidoglycan of bacterial cell walls. I. Utilization of uridine diphosphate acetylmuramyl pentapeptide and uridine diphosphate acetylglucosamine for peptidoglycan synthesis by particulate enzymes from Staphylococcus aureus and Micrococcus lysodeikticus.

Authors:  J S Anderson; P M Meadow; M A Haskin; J L Strominger
Journal:  Arch Biochem Biophys       Date:  1966-09-26       Impact factor: 4.013

10.  PROTOPLAST LYSIS AND INHIBITION OF GROWTH OF BACILLUS LICHENIFORMIS BY BACITRACIN.

Authors:  J E SNOKE; N CORNELL
Journal:  J Bacteriol       Date:  1965-02       Impact factor: 3.490
  10 in total
  101 in total

1.  Peptide antibiotic sensing and detoxification modules of Bacillus subtilis.

Authors:  Anna Staroń; Dora Elisabeth Finkeisen; Thorsten Mascher
Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

2.  Molecular mechanism of target recognition by subtilin, a class I lanthionine antibiotic.

Authors:  Judicaël Parisot; Sarah Carey; Eefjan Breukink; Weng C Chan; Arjan Narbad; Boyan Bonev
Journal:  Antimicrob Agents Chemother       Date:  2007-11-12       Impact factor: 5.191

3.  The transfer of mannose from guanosine diphosphate mannose to dolichol phosphate and protein by pig liver endoplasmic reticulum.

Authors:  J B Richards; F W Hemming
Journal:  Biochem J       Date:  1972-11       Impact factor: 3.857

4.  Selective Inhibition of Neisseria gonorrhoeae by a Dithiazoline in Mixed Infections with Lactobacillus gasseri.

Authors:  Jonathan D Lenz; Kristina A Shirk; Adrienne Jolicoeur; Joseph P Dillard
Journal:  Antimicrob Agents Chemother       Date:  2018-11-26       Impact factor: 5.191

5.  Role of a sugar-lipid intermediate in colanic acid synthesis by Escherichia coli.

Authors:  J G Johnson; D B Wilson
Journal:  J Bacteriol       Date:  1977-01       Impact factor: 3.490

6.  Acquired bacitracin resistance in Enterococcus faecalis is mediated by an ABC transporter and a novel regulatory protein, BcrR.

Authors:  Janet M Manson; Stefanie Keis; John M B Smith; Gregory M Cook
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

7.  Characterization of the mechanism of the Staphylococcus aureus cell envelope by bacitracin and bacitracin-metal ions.

Authors:  Zu-De Qi; Yi Lin; Bo Zhou; Xiao-Di Ren; Dai-Wen Pang; Yi Liu
Journal:  J Membr Biol       Date:  2008-10-15       Impact factor: 1.843

8.  Inhibition of peptidoglycan synthesis by the antibiotic diumycin A.

Authors:  E J Lugtenberg; J A Hellings; G J van de Berg
Journal:  Antimicrob Agents Chemother       Date:  1972-12       Impact factor: 5.191

9.  Accumulation of heptaprenyl diphosphate sensitizes Bacillus subtilis to bacitracin: implications for the mechanism of resistance mediated by the BceAB transporter.

Authors:  Anthony W Kingston; Heng Zhao; Gregory M Cook; John D Helmann
Journal:  Mol Microbiol       Date:  2014-05-23       Impact factor: 3.501

10.  Undecaprenyl pyrophosphate involvement in susceptibility of Bacillus subtilis to rare earth elements.

Authors:  Takashi Inaoka; Kozo Ochi
Journal:  J Bacteriol       Date:  2012-08-17       Impact factor: 3.490
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