Literature DB >> 13859449

Requirement of divalent metal ions for bacitracin activity.

R H ADLER, J E SNOKE.   

Abstract

Adler, Richard H. (University of California, Los Angeles) and John E. Snoke. Requirement of divalent metal ions for bacitracin activity. J. Bacteriol. 83:1315-1317. 1962.-The antibiotic activity of bacitracin towards Staphylococcus aureus is completely suppressed by ethylenediaminetetraacetate. The conclusion that bacitracin activity requires the presence of metal ions is supported by the demonstration that the addition of a number of divalent ions reverses the effect of ethylenediaminetetraacetate. The most active of these ions, cadmium, manganese, and zinc, directly enhance the activity of bacitracin.

Entities:  

Keywords:  BACITRACIN/pharmacology; IONS; STAPHYLOCOCCUS/pharmacology

Mesh：

Substances：

Year:  1962        PMID： 13859449      PMCID： PMC279452          DOI： 10.1128/jb.83.6.1315-1317.1962

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  2 in total

1.  BACITRACIN: A NEW ANTIBIOTIC PRODUCED BY A MEMBER OF THE B. SUBTILIS GROUP.

Authors:  B A Johnson; H Anker; F L Meleney
Journal:  Science       Date:  1945-10-12       Impact factor: 47.728
  2 in total
  6 in total

1.  Attempted stabilization of autoclaved bacitracin by metallic ions.

Authors:  M L CRISLER; E D WEINBERG
Journal:  J Bacteriol       Date:  1963-02       Impact factor: 3.490

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Journal:  Curr Microbiol       Date:  2005-10-05       Impact factor: 2.188

3.  Bacitracin-induced proteins in Bacillus subtilis and Bacillus thuringiensis and their relationship with resistance.

Authors:  M García-Patrone
Journal:  Antimicrob Agents Chemother       Date:  1990-05       Impact factor: 5.191

4.  Genetic evidence for an alternative citrate-dependent biofilm formation pathway in Staphylococcus aureus that is dependent on fibronectin binding proteins and the GraRS two-component regulatory system.

Authors:  Robert M Q Shanks; Michael A Meehl; Kimberly M Brothers; Raquel M Martinez; Niles P Donegan; Martha L Graber; Ambrose L Cheung; George A O'Toole
Journal:  Infect Immun       Date:  2008-03-17       Impact factor: 3.441

5.  Mechanism of action of bacitracin: complexation with metal ion and C 55 -isoprenyl pyrophosphate.

Authors:  K J Stone; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1971-12       Impact factor: 11.205

6.  PROTOPLAST LYSIS AND INHIBITION OF GROWTH OF BACILLUS LICHENIFORMIS BY BACITRACIN.

Authors:  J E SNOKE; N CORNELL
Journal:  J Bacteriol       Date:  1965-02       Impact factor: 3.490
  6 in total

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