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Literature DB >> 4670441

Inhibition of peptidoglycan synthesis by the antibiotic diumycin A.

E J Lugtenberg, J A Hellings, G J van de Berg.

Abstract

Diumycin A, a new antibiotic, was found to inhibit cell wall synthesis by Staphylococcus aureus, a phenomenon accompanied by accumulation of uridine-5'-diphosphate-N-acetyl-muramyl-pentapeptide. The antibiotic inhibited in vitro peptidoglycan synthesis by particulate preparations of Bacillus stearothermophilus and Escherichia coli by preventing the utilization of N-acetyl-glucosamine-N-acetyl-muramyl-pentapeptide. In contrast to vancomycin, the antibiotics diumycin, prasinomycin, moenomycin, 11.837 RP, and enduracidin do not inhibit particulate d-alanine carboxypeptidase.

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Year: 1972 PMID： 4670441 PMCID： PMC444343 DOI： 10.1128/AAC.2.6.485

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

27 in total

1. Microbial uridine-5'-pyrophosphate N-acetylamino sugar compounds. I. Biology of the penicillin-induced accumulation.

Authors: J L STROMINGER
Journal: J Biol Chem Date: 1957-01 Impact factor: 5.157

2. Biosynthesis of the peptidoglycan of bacterial cell walls. 8. Peptidoglycan transpeptidase and D-alanine carboxypeptidase: penicillin-sensitive enzymatic reaction in strains of Escherichia coli.

Authors: K Izaki; M Matsuhashi; J L Strominger
Journal: J Biol Chem Date: 1968-06-10 Impact factor: 5.157

3. Biosynthesis of the peptidoglycan of bacterial cell walls. XIV. Purification and properties of two D-alanine carboxypeptidases from Escherichia coli.

Authors: K Izaki; J L Strominger
Journal: J Biol Chem Date: 1968-06-10 Impact factor: 5.157

4. Biosynthesis of the peptidoglycan of bacterial cell walls. XII. Inhibition of cross-linking by penicillins and cephalosporins: studies in Staphylococcus aureus in vivo.

Authors: D J Tipper; J L Strominger
Journal: J Biol Chem Date: 1968-06-10 Impact factor: 5.157

5. The prasinomycins: antibiotics containing phosphorus.

Authors: F L Weisenborn; J L Bouchard; D Smith; F Pansy; G Maestrone; G Miraglia; E Meyers
Journal: Nature Date: 1967-03-18 Impact factor: 49.962

6. On the Streptomyces albus G DD carboxypeptidase mechanism of action of penicillin, vancomycin, and ristocetin.

Authors: M Leyh-Bouille; J M Ghuysen; M Nieto; H R Perkins; K H Schleifer; O Kandler
Journal: Biochemistry Date: 1970-07-21 Impact factor: 3.162

7. Penicillin: its basic site of action as an inhibitor of a peptide cross-linking reaction in cell wall mucopeptide synthesis.

Authors: E M Wise; J T Park
Journal: Proc Natl Acad Sci U S A Date: 1965-07 Impact factor: 11.205

8. Selective inhibition of enzymes utilizing alanine in the biosynthesis of peptidoglycan.

Authors: F C Neuhaus
Journal: Antimicrob Agents Chemother (Bethesda) Date: 1967

9. Biosynthesis of the peptidoglycan of bacterial cell walls. I. Utilization of uridine diphosphate acetylmuramyl pentapeptide and uridine diphosphate acetylglucosamine for peptidoglycan synthesis by particulate enzymes from Staphylococcus aureus and Micrococcus lysodeikticus.

Authors: J S Anderson; P M Meadow; M A Haskin; J L Strominger
Journal: Arch Biochem Biophys Date: 1966-09-26 Impact factor: 4.013

10. Modifications of the acyl-D-alanyl-D-alanine terminus affecting complex-formation with vancomycin.

Authors: M Nieto; H R Perkins
Journal: Biochem J Date: 1971-08 Impact factor: 3.857

3 in total

1. Gardimycin, a new antibiotic inhibiting peptidoglycan synthesis.

Authors: S Somma; W Merati; F Parenti
Journal: Antimicrob Agents Chemother Date: 1977-03 Impact factor: 5.191

2. In vitro synthesis of peptidoglycan by beta-lactam-sensitive and -resistant strains of Neisseria gonorrhoeae: effects of beta-lactam and other antibiotics.

Authors: C A Brown; H R Perkins
Journal: Antimicrob Agents Chemother Date: 1979-07 Impact factor: 5.191

3. Additional antibiotic inhibitors of peptidoglycan synthesis.

Authors: P E Linnett; J L Strominger
Journal: Antimicrob Agents Chemother Date: 1973-09 Impact factor: 5.191

3 in total