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Literature DB >> 429552

Further studies of the frequency and significance of the Tgamma-chain of human fetal hemoglobin.

W A Schroeder, T H Huisman, G D Efremov, J R Shelton, J B Shelton, R Phillips, A Reese, M Gravely, J M Harrison, H Lam.

Abstract

A further study of the Tgamma-chain in a variety of conditions has revealed its presence in the cord bloods of ethnic groups previously unstudied. Heterozygous newborn average 17-19% Tgamma-chain while the mean value in four presumed homozygotes was 31%. The Tgamma-chain is readily detectable in beta-thalassemia of various ethnic groups (although infrequent in Blacks) as well as in deltabeta-thalassemia. Studies of a few families have provided an opportunity to determine whether or not certain individuals are heterozygous or homozygous for the Tgamma-gene. The Tgamma-chain has not been detected in the human fetal hemoglobin that is synthesized in increased amounts in persons with the hereditary persistence of fetal hemoglobin. Although the Tgamma-chain is detectable in sickle cell anemia, its frequency appears to be lower than in normal individuals. By focusing upon the relationship of the percentage of Tgamma-chain to the sources of human fetal globulin from determinants in cis and in trans, the conclusion has been reached that the Tgamma-chain is the product of a mutant Agamma-locus which should be named the TAgamma-chain.

Entities: Chemical Disease Species

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Year: 1979 PMID： 429552 PMCID： PMC371949 DOI： 10.1172/JCI109299

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

20 in total

1. The T gamma chain of human fetal hemoglobin at birth and in several abnormal hematologic conditions.

Authors: T H Huisman; W A Schroeder; A Reese; J B Wilson; H Lam; R Shelton; J B Shelton; S Baker
Journal: Pediatr Res Date: 1977-10 Impact factor: 3.756

2. A direct estimate of the number of human gamma-globin genes.

Authors: J Old; J B Clegg; D J Weatherall; S Ottolenghi; P Comi; B Giglioni; J Mitchell; P Tolstoshev; R Williamson
Journal: Cell Date: 1976-05 Impact factor: 41.582

3. Globin synthesis in the Jamaican Negro with beta-thalassaemia.

Authors: S Friedman; E Schwartz; V Ahern; E Ahern
Journal: Br J Haematol Date: 1974-12 Impact factor: 6.998

4. The present status of the heterogeneity of fetal hemoglobin in beta-thalassemia: an attempt to unify some observations in thalassemia and related conditions.

Authors: T H Huisman; W A Schroeder; G D Efremov; H Duma; B Mladenovski; C B Hyman; E A Rachmilewitz; N Bouver; A Miller; A Brodie; J R Shelton; J B Shelton; G Apell
Journal: Ann N Y Acad Sci Date: 1974 Impact factor: 5.691

5. Non-synchronized suppression of postnatal activity in non-allelic genes which synthesize the Ggamma chain in human foetal haemoglobin.

Authors: W A Schroeder; W H Bannister; J L Grech; A K Brown; R N Wrightstone; T H Huisman
Journal: Nat New Biol Date: 1973-07-18

6. Haemoglobin F Melbourne Ggamma 16 Gly leads to Arg and haemoglobin F carlton Ggamma 121 Glu leads to Lys. Further evidence for varied activity of gamma-chain genes.

Authors: S O Brennan; M B Smith; R W Carrell
Journal: Biochim Biophys Acta Date: 1977-02-22

7. Anomaly in the gamma chain heterogeneity of the newborn.

Authors: T H Huisman; W A Schroeder; A Felice; D Powars; B Ringelhann
Journal: Nature Date: 1977-01-06 Impact factor: 49.962

8. Demonstration of two alpha-globin genes per human haploid genome for normals and Hb J Mexico.

Authors: P Tolstoshev; R Williamson; J Eskdale; G Verdier; J Godet; V Nigon; G Trabuchet; M Benabadji
Journal: Eur J Biochem Date: 1977-08-15

9. Search for nonallelic structural genes for gamma-chains of fetal hemoglobin in some primates.

Authors: T H Huisman; W A Schroeder; M E Keeling; N Gengozian; A Miller; A R Brodie; J R Shelton; J B Shelton; G Apell
Journal: Biochem Genet Date: 1973-11 Impact factor: 1.890

10. The V gamma chain of fetal hemoglobin of the orangutan.

Authors: W A Schroeder; J R Shelton; J B Shelton; T H Huisman
Journal: Biochem Genet Date: 1978-12 Impact factor: 1.890

8 in total

1. Frequency of human A gamma 75Thr globin chain in a population from Tunisia.

Authors: M P Lefranc; G Lefranc; M Farhat; R Jmour; K Boukef; Y Beuzard; F Galacteros; J Rosa
Journal: Hum Genet Date: 1981 Impact factor: 4.132

2. The frequency of the gamma chain variant A gamma T in different populations, and its use in evaluating gamma gene expression in association with thalassemia.

Authors: T H Huisman; F Kutlar; T Nakatsuji; A Bruce-Tagoe; Y Kilinç; M N Cauchi; C Romero Garcia
Journal: Hum Genet Date: 1985 Impact factor: 4.132

3. Does G gamma/A gamma ratio and Hb F level influence the severity of sickle cell anaemia.

Authors: M A el-Hazmi; H M Bahakim; A S Warsy; A al-Momen; A al-Wazzan; I al-Fawwaz; S Huraib; M Harakati
Journal: Mol Cell Biochem Date: 1993-07-07 Impact factor: 3.396

4. Hemoglobin abnormalities. An evaluation on new-born infants and their mothers in a maternity unit close to Brazzaville (P.R. Congo).

Authors: M Lallemant; F Galacteros; S Lallemant-Lecoeur; J Feingold; P Carnevale; V Boukila; J Mouchet; J Rosa
Journal: Hum Genet Date: 1986-09 Impact factor: 4.132

8. DNA polymorphisms in North Sardinian newborns and their linkage with abnormal gamma globin gene arrangements and with beta (0) -thalassemia.

Authors: Y Hattori; F Kutlar; S S Chen; T H Huisman; P Demuro; M Formato; L Manca; B Masala
Journal: Biochem Genet Date: 1986-10 Impact factor: 1.890