Literature DB >> 2468496

The gamma-chain heterogeneity of haemoglobin F in German infants.

A Pekrun1, M Scharnetzky, M Gahr, W Schröter.   

Abstract

gamma-chain heterogeneity of haemoglobin F was studied in German full-term and preterm infants up to 12 months old. The A gamma T-gene frequency calculated was about 19%. In most cases with A gamma I-/A gamma T-chain heterogeneity A gamma I-chains predominated over A gamma T-chains. There was no difference between infants with or without the A gamma T-chain concerning haemoglobin F-concentration, F-cell percentage or G gamma-chain percentage. The G gamma-chains accounted for 69.2% +/- 3.3% (SD) of the total gamma-chains in full-term newborn infants with a decrease to 42.5% +/- 6.5% during the first 6 months. Comparison of the G gamma-chain decrease in preterm and in full-term newborn infants suggests a more pronounced decrease during extrauterine life than during the intrauterine course.

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Year:  1989        PMID： 2468496     DOI： 10.1007/bf00444119

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN： 0340-6199            Impact factor:   3.183


  17 in total

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Authors:  K BETKE; H R MARTI; I SCHLICHT
Journal:  Nature       Date:  1959-12-12       Impact factor: 49.962

2.  The frequency of the gamma chain variant A gamma T in different populations, and its use in evaluating gamma gene expression in association with thalassemia.

Authors:  T H Huisman; F Kutlar; T Nakatsuji; A Bruce-Tagoe; Y Kilinç; M N Cauchi; C Romero Garcia
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

3.  -G gamma A gamma-Thalassemia and gamma-chain variants in Chinese newborn babies.

Authors:  Y T Zeng; S Z Huang; T Nakatsuji; T H Huisman
Journal:  Am J Hematol       Date:  1985-03       Impact factor: 10.047

4.  [A simplified modification of the acid elution for the cytological demonstration of fetal hemoglobin].

Authors:  K Nierhaus; K Betke
Journal:  Klin Wochenschr       Date:  1968-01-01

5.  The chemical heterogeneity of the fetal hemoglobin of black newborn babies and adults: a reevaluation.

Authors:  T H Huisman; C Altay
Journal:  Blood       Date:  1981-09       Impact factor: 22.113

6.  Anomaly in the gamma chain heterogeneity of the newborn.

Authors:  T H Huisman; W A Schroeder; A Felice; D Powars; B Ringelhann
Journal:  Nature       Date:  1977-01-06       Impact factor: 49.962

7.  Two novel arrangements of the human fetal globin genes: G gamma-G gamma and A gamma-A gamma.

Authors:  P A Powers; C Altay; T H Huisman; O Smithies
Journal:  Nucleic Acids Res       Date:  1984-09-25       Impact factor: 16.971

8.  The chemical heterogeneity of human hemoglobin F. Direct evidence for the existence of three types of gamma chain, the G gamma I, A gamma I, and A gamma T chains.

Authors:  G D Efremov; J B Wilson; T H Huisman
Journal:  Biochim Biophys Acta       Date:  1979-08-28

9.  The gamma chain heterogeneity of fetal hemoglobin in black beta-thalassemia and HPFH heterozygotes.

Authors:  T H Huisman; M E Gravely; B Webber; K Okonjo; J Henson; A L Reese
Journal:  Blood       Date:  1981-07       Impact factor: 22.113

10.  Further studies of the frequency and significance of the Tgamma-chain of human fetal hemoglobin.

Authors:  W A Schroeder; T H Huisman; G D Efremov; J R Shelton; J B Shelton; R Phillips; A Reese; M Gravely; J M Harrison; H Lam
Journal:  J Clin Invest       Date:  1979-02       Impact factor: 14.808
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