Literature DB >> 4275394

Human pituitary growth hormone: isolation and properties of two biologically active fragments from plasmin digests.

C H Li, L Gráf.   

Abstract

Two biologically active fragments have been isolated from plasmic digests of human pituitary growth hormone. It was shown that these two fragments were derived from the cleavage of the Arg-Thr (positions 134-135) and the Lys-Gln (positions 140-141) bonds of the hormone: one has 134 amino acids and the other 51 amino acids, respectively. The two fragments were active in the rat tibia and pigeon crop-sac tests, as well as in complement fixation experiments.

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Year:  1974        PMID： 4275394      PMCID： PMC388191          DOI： 10.1073/pnas.71.4.1197

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

1.  Isohormones of human growth hormone. II. Plasmin-catalyzed transformation and increase in prolactin biological activity.

Authors:  R A Yadley; A Chrambach
Journal:  Endocrinology       Date:  1973-10       Impact factor: 4.736

2.  Isohormones of human growth hormone. 3. Isolation by preparative polyacrylamide gel electrophoresis and characterization.

Authors:  R A Yadley; D Rodbard; A Chrambach
Journal:  Endocrinology       Date:  1973-10       Impact factor: 4.736

3.  Isohormones of human growth hormone. I. Characterization by electrophoresis and isoelectric focusing in polyacrylamide gel.

Authors:  A Chrambach; R A Yadley; M Ben-David; D Rodbard
Journal:  Endocrinology       Date:  1973-10       Impact factor: 4.736

4.  Hydrolysis of proteins with p-toluenesulfonic acid. Determination of tryptophan.

Authors:  T Y Liu; Y H Chang
Journal:  J Biol Chem       Date:  1971-05-10       Impact factor: 5.157

5.  Human prolactin: isolation and some properties.

Authors:  U J Lewis; R N Singh; B K Seavey
Journal:  Biochem Biophys Res Commun       Date:  1971-09       Impact factor: 3.575

6.  Human pituitary growth hormone. XI. Rate of hydrolysis by trypsin, chymotrypsin, and pepsin; effect of trypsin on the biological activity.

Authors:  C H Li; G Samuelsson
Journal:  Mol Pharmacol       Date:  1965-07       Impact factor: 4.436

7.  Estimation of the molecular weights of the multiple components of growth hormone and prolactin.

Authors:  E V Cheever; U J Lewis
Journal:  Endocrinology       Date:  1969-09       Impact factor: 4.736

8.  Bio-assay of prolactin. Analysis of the pigeon crop-sac response to local prolactin injection by an objective and quantitative method.

Authors:  C S Nicoll
Journal:  Endocrinology       Date:  1967-04       Impact factor: 4.736

9.  Separation of dansyl-amino acids by polyamide layer chromatography.

Authors:  K R Woods; K T Wang
Journal:  Biochim Biophys Acta       Date:  1967-02-21

10.  Retention of the biological potency of human pituitary growth hormone after reduction and carbamidomethylation.

Authors:  J S Dixon; C H Li
Journal:  Science       Date:  1966-11-11       Impact factor: 47.728
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  16 in total

1.  Biological properties of plasmin digests of S-carbamidomethylated human growth hormone.

Authors:  C R Reagan; J B Mills; J L Kostyo; A E Wilhelmi
Journal:  Proc Natl Acad Sci U S A       Date:  1975-05       Impact factor: 11.205

2.  Preparation of a disulfide-linked dimer of human placental lactogen fragment 1--134 with immunologic and biologic activity.

Authors:  J Russell; L M Sherwood; K Kowalski; A B Schneider
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

3.  Noncovalent interaction of the NH2-terminal fragment of human somatotropin with the COOH-terminal fragment of human choriomammotropin to generate growth-promoting activity.

Authors:  C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

4.  Semisynthesis of human somatotropin analogs.

Authors:  C H Li; J Blake
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

5.  Activity of human growth hormone and related polypeptides on the adipose conversion of 3T3 cells.

Authors:  M Morikawa; H Green; U J Lewis
Journal:  Mol Cell Biol       Date:  1984-02       Impact factor: 4.272

6.  Immunoreactivity and receptor binding of mixed recombinants of human growth hormone and chorionic somatomammotropin.

Authors:  S Burstein; M M Grumbach; S L Kaplan; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

7.  Receptor-binding and down-regulatory properties of 22000-Mr human growth hormone and its natural 20000-Mr variant on IM-9 human lymphocytes.

Authors:  J Smal; J Closset; G Hennen; P de Meyts
Journal:  Biochem J       Date:  1985-01-15       Impact factor: 3.857

8.  Human pituitary growth hormone: a biologically active hendekakaihekaton peptide fragment corresponding to amino-acid residues 15-125 in the hormone molecule.

Authors:  C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205

9.  Human pituitary growth hormone: restoration of full biological activity by noncovalent interaction of two fragments of the hormone.

Authors:  C H Li; T A Bewley
Journal:  Proc Natl Acad Sci U S A       Date:  1976-05       Impact factor: 11.205

10.  Growth hormone modulation of murine erythroleukemia cell growth in vitro.

Authors:  D W Golde; N Bersch; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205
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