Literature DB >> 4275130

Purification and amino acid analysis of an active site peptide from thymidylate synthetase containing covalently bound 5-fluoro-2'-deoxyuridylate and methylenetetrahydrofolate.

H Sommer, D V Santi.   

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Year:  1974        PMID: 4275130     DOI: 10.1016/0006-291x(74)90601-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN: 0006-291X            Impact factor:   3.575


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  26 in total

1.  ATP chemosensitivity testing of new antitumor duplex drugs linking 3`-C-ethynylycytidine (ECyd) and 2´-deoxy-5-fluorouridine (5-FdU) in comparison to standard cytostatica and combinations thereof.

Authors:  Sarah Schott; Markus Wallwiener; Beate Kootz; Harald Seeger; Tanja Fehm; Hans Neubauer
Journal:  Invest New Drugs       Date:  2009-12-09       Impact factor: 3.850

2.  Cytostatic activity of the duplex drug linking 2'-deoxy-5-fluorouridine (5FdU) with 3'-C-ethynylcytidine (ECyd) against gastric adenocarcinoma cell lines.

Authors:  Jürgen Weinreich; Sarah Schott; Ingmar Königsrainer; Derek Zieker; Alfred Königsrainer; Herbert Schott
Journal:  Invest New Drugs       Date:  2010-07-02       Impact factor: 3.850

Review 3.  Spliceosomal snRNA modifications and their function.

Authors:  John Karijolich; Yi-Tao Yu
Journal:  RNA Biol       Date:  2010-03-14       Impact factor: 4.652

Review 4.  Targeting nuclear thymidylate biosynthesis.

Authors:  James Chon; Patrick J Stover; Martha S Field
Journal:  Mol Aspects Med       Date:  2016-11-19

Review 5.  Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years.

Authors:  Mariusz Panczyk
Journal:  World J Gastroenterol       Date:  2014-08-07       Impact factor: 5.742

Review 6.  5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development.

Authors:  J L Grem
Journal:  Invest New Drugs       Date:  2000-11       Impact factor: 3.850

Review 7.  Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?

Authors:  Shayna L Showalter; Timothy N Showalter; Agnes Witkiewicz; Robert Havens; Eugene P Kennedy; Tomas Hucl; Scott E Kern; Charles J Yeo; Jonathan R Brody
Journal:  Cancer Biol Ther       Date:  2008-04-21       Impact factor: 4.742

8.  Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.

Authors:  B Ullman; M Lee; D W Martin; D V Santi
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

9.  Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion.

Authors:  C E Myers; R C Young; B A Chabner
Journal:  J Clin Invest       Date:  1975-11       Impact factor: 14.808

10.  Amino acid sequence at the FdUMP binding site of thymidylate synthetase.

Authors:  R L Bellisario; G F Maley; J H Galivan; F Maley
Journal:  Proc Natl Acad Sci U S A       Date:  1976-06       Impact factor: 11.205

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