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Literature DB >> 20215871

Spliceosomal snRNA modifications and their function.

Abstract

Spliceosomal snRNAs are extensively 2'-O-methylated and pseudouridylated. The modified nucleotides are relatively highly conserved across species, and are often clustered in regions of functional importance in pre-mRNA splicing. Over the past decade, the study of the mechanisms and functions of spliceosomal snRNA modifications has intensified. Two independent mechanisms behind these modifications, RNA-independent (protein-only) and RNA-dependent (RNA-guided), have been discovered. The role of spliceosomal snRNA modifications in snRNP biogenesis and spliceosome assembly has also been verified.

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Year: 2010 PMID： 20215871 PMCID： PMC4154345 DOI： 10.4161/rna.7.2.11207

Source DB: PubMed Journal: RNA Biol ISSN： 1547-6286 Impact factor: 4.652

140 in total

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80 in total

Review 1. Functions and mechanisms of spliceosomal small nuclear RNA pseudouridylation.

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Journal: Wiley Interdiscip Rev RNA Date: 2011-02-18 Impact factor: 9.957

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Journal: RNA Biol Date: 2016-10-24 Impact factor: 4.652