| Literature DB >> 426582 |
D J Chapron, D Mumford, G I Pitegoff.
Abstract
Accelerated quinidine metabolism was observed in a 94-year-old woman also receiving daily doses of digoxin and pentobarbital sodium. Discontinuation of pentobarbital produced a sharp increase in serum digoxin concentrations coupled with symptoms highly suggestive of digoxin toxicity. Associated with these findings was 3.8-fold increase in quinidine half-life. These data seemed consistent with an interaction between quinidine and digoxin that was precipitated by pentobarbital withdrawal.Entities:
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Year: 1979 PMID： 426582
Source DB: PubMed Journal: Arch Intern Med ISSN： 0003-9926